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{{enzyme
| Name = N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
| EC_number = 2.4.1.225
| CAS_number = 145539-84-0
| IUBMB_EC_number = 2/4/1/225
| GO_code = 0050509
| image =
| width =
| caption =
}}
In [[enzymology]], a '''N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase''' ({{EC number|2.4.1.225}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan <math>\rightleftharpoons</math> UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan


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The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[UDP-alpha-D-glucuronate]], [[N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-]], and [[proteoglycan]], whereas its 3 [[product (chemistry)|products]] are [[uridine diphosphate|UDP]], [[beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-]], and [[beta-D-glucuronosyl-proteoglycan]].
 
This enzyme belongs to the family of [[glycosyltransferase]]s, specifically the hexosyltransferases. The systematic name of this enzyme class is '''UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase'''. Other names in common use include '''N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase''', and '''heparan glucuronyltransferase II'''. This enzyme participates in [[heparan sulfate biosynthesis]] and [[glycan structures - biosynthesis 1]]. 
 
==References==
{{reflist|1}}
* {{cite journal | author = K, Lindahl U, Kusche-Gullberg M | date = 2000 | title = The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis | journal = EMBO Reports  | volume = 1 | pages = 282&ndash;6  | pmid = 11256613 | doi = 10.1093/embo-reports/kvd045 | issue = 3 | pmc = 1083719 }}
* {{cite journal | author = Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K | date = 1998 | title = The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate | journal = J. Biol. Chem. | volume = 273 | pages = 26265&ndash;8  | pmid = 9756849 | doi = 10.1074/jbc.273.41.26265 | issue = 41 }}
 
{{enzyme-stub}}
 
[[Category:EC 2.4.1]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 23:27, 17 March 2013

Template:Enzyme In enzymology, a N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan

The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, [[N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-]], and proteoglycan, whereas its 3 products are UDP, [[beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-]], and beta-D-glucuronosyl-proteoglycan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase. Other names in common use include N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase, and heparan glucuronyltransferase II. This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.

References

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Template:Enzyme-stub