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{{enzyme
| Name = (R)-6-hydroxynicotine oxidase
| EC_number = 1.5.3.6
| CAS_number = 37233-46-8
| IUBMB_EC_number = 1/5/3/6
| GO_code = 0018530
| image =
| width =
| caption =
}}
In [[enzymology]], a '''(R)-6-hydroxynicotine oxidase''' ({{EC number|1.5.3.6}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:(R)-6-hydroxynicotine + H<sub>2</sub>O + O<sub>2</sub> <math>\rightleftharpoons</math> 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H<sub>2</sub>O<sub>2</sub>
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[(R)-6-hydroxynicotine]], [[water|H<sub>2</sub>O]], and [[oxygen|O<sub>2</sub>]], whereas its two [[product (chemistry)|products]] are [[1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one]] and [[hydrogen peroxide|H<sub>2</sub>O<sub>2</sub>]].
 
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is '''(R)-6-hydroxynicotine:oxygen oxidoreductase'''. Other names in common use include '''D-6-hydroxynicotine oxidase''', and '''6-hydroxy-D-nicotine oxidase'''. It employs one [[cofactor (biochemistry)|cofactor]], [[FAD]].
 
==Structural studies==
 
As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2BVF}}, {{PDB link|2BVG}}, and {{PDB link|2BVH}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Bruhmuller M, Mohler H, Decker K | date = 1972 | title = Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase | journal = Eur. J. Biochem. | volume = 29 | pages = 143&ndash;51  | pmid = 4628374 | doi = 10.1111/j.1432-1033.1972.tb01968.x | issue = 1 }}
* {{cite journal | author = Decker K, Bleeg H | date = 1965 | title = Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans | journal = Biochim. Biophys. Acta.  | volume = 105 | pages = 313&ndash;24  | pmid = 5849820 | issue = 2 }}
 
[[Category:EC 1.5.3]]
[[Category:Flavin enzymes]]
[[Category:Enzymes of known structure]]

Latest revision as of 21:12, 17 March 2013

Template:Enzyme In enzymology, a (R)-6-hydroxynicotine oxidase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

(R)-6-hydroxynicotine + H2O + O2 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2

The 3 substrates of this enzyme are (R)-6-hydroxynicotine, H2O, and O2, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang