Sepiapterin reductase: Difference between revisions

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== variously ==
{{enzyme
| Name = testosterone 17-beta-dehydrogenase (NAD<sup>+</sup>)
| EC_number = 1.1.1.63
| CAS_number = 9028-62-0
| IUBMB_EC_number = 1/1/1/63
| GO_code = 0050327
| image =
| width =
| caption =
}}
{{enzyme
| Name = testosterone 17-beta-dehydrogenase (NADP<sup>+</sup>)
| EC_number = 1.1.1.64
| CAS_number = 9028-63-1
| IUBMB_EC_number = 1/1/1/64
| GO_code = 0047045
| image =
| width =
| caption =
}}
In [[enzymology]], a '''testosterone 17beta-dehydrogenase''' is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] between [[testosterone]] and [[androst-4-ene-3,17-dione]].


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This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''17beta-hydroxysteroid:NAD<sup>+</sup> 17-oxidoreductase'''. Other names in common use include '''17-ketoreductase''', and '''17beta-HSD'''. This enzyme participates in [[androgen and estrogen metabolism]].
 
 
  <li>[http://mlab.test.quonic.net/wiki/ugg-factory-shop-christchurch-early-july http://mlab.test.quonic.net/wiki/ugg-factory-shop-christchurch-early-july]</li>
==Variants==
 
There are two variants of the enzyme, one that uses [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]] as a substrate, and one that uses [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]] as acceptor.
  <li>[http://forum.gamemodeller.com/default.aspx?g=posts&t=290073 http://forum.gamemodeller.com/default.aspx?g=posts&t=290073]</li>
 
 
===NAD<sup>+</sup>===
  <li>[http://ciarcr.org/spip.php?article310/ http://ciarcr.org/spip.php?article310/]</li>
This variant of testosterone 17beta-dehydrogenase ({{EC number|1.1.1.63}}) catalyzes the reaction
 
 
  <li>[http://yijiansong.u092.iiddcc.com/news/html/?344822.html http://yijiansong.u092.iiddcc.com/news/html/?344822.html]</li>
:testosterone + NAD<sup>+</sup> <math>\rightleftharpoons</math> androst-4-ene-3,17-dione + NADH + H<sup>+</sup>
 
 
  <li>[http://globaldialogue2013.go.tz/gdforum/activity http://globaldialogue2013.go.tz/gdforum/activity]</li>
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[testosterone]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[androst-4-ene-3,17-dione]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
 
 
</ul>
===NADP<sup>+</sup>===
This variant of testosterone 17beta-dehydrogenase ({{EC number|1.1.1.64}}) catalyzes the reaction
 
:testosterone + NADP<sup>+</sup> <math>\rightleftharpoons</math> androst-4-ene-3,17-dione + NADPH + H<sup>+</sup>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[testosterone]] and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[androst-4-ene-3,17-dione]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Endahl GL, Kochakian CD, Hamm D | date = 1960 | title = Separation of a Triphosphopyridine Nucleotide-specific from a Diphosphopyridine Nucleotide-specific 17''β''-Hydroxy-(testosterone)dehydrogenase of Guinea Pig Liver | journal = J. Biol. Chem. | volume = 235 | pages = 2792&ndash;6 | pmid = 13696735 }}
* {{cite journal | author = Sweat ML, Samuels LT, Lumry R | date = 1950 | title = Preparation and haracterization of the enzyme which converts testosterone to androstenedione | journal = J. Biol. Chem. | volume = 185 | pages = 75&ndash;84 | pmid = 15436478 | issue = 1 }}
* {{cite journal | author = Villee CA and Spencer JM | date = 1960 | title = Some Properties of the Pyridine Nucleotide-specific 17''β''-Hydroxy Steroid Dehydrogenases of Guinea Pig Liver | journal = J. Biol. Chem. | volume = 235 | pages = 3615&ndash;3619 | pmid=13781425}}
 
[[Category:EC 1.1.1]]
[[Category:NADH-dependent enzymes]]
[[Category:NADPH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]
[[Category:Enzymes of known structure]]
[[Category:Testosterone]]
 
 
{{1.1.1-enzyme-stub}}

Revision as of 00:39, 30 January 2014

Template:Enzyme Template:Enzyme In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction between testosterone and androst-4-ene-3,17-dione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Variants

There are two variants of the enzyme, one that uses NAD+ as a substrate, and one that uses NADP+ as acceptor.

NAD+

This variant of testosterone 17beta-dehydrogenase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) catalyzes the reaction

testosterone + NAD+ ⇌ androst-4-ene-3,17-dione + NADH + H+

Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.

NADP+

This variant of testosterone 17beta-dehydrogenase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) catalyzes the reaction

testosterone + NADP+ ⇌ androst-4-ene-3,17-dione + NADPH + H+

Thus, the two substrates of this enzyme are testosterone and NADP+, whereas its 3 products are androst-4-ene-3,17-dione, NADPH, and H+.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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Template:1.1.1-enzyme-stub