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{{enzyme
| Name = saccharopine dehydrogenase (NAD+, L-lysine-forming)
| EC_number = 1.5.1.7
| CAS_number = 9073-96-5
| IUBMB_EC_number = 1/5/1/7
| GO_code = 0004754
| image =
| width =
| caption =
}}
In [[enzymology]], a '''saccharopine dehydrogenase (NAD+, L-lysine-forming)''' ({{EC number|1.5.1.7}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:N<sub>6</sub>-(L-1,3-dicarboxypropyl)-L-lysine + NAD<sup>+</sup> + H<sub>2</sub>O <math>\rightleftharpoons</math> L-lysine + 2-oxoglutarate + NADH + H<sup>+</sup>
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[N6-(L-1,3-dicarboxypropyl)-L-lysine]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[water|H<sub>2</sub>O]], whereas its 4 [[product (chemistry)|products]] are [[L-lysine]], [[2-oxoglutarate]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
 
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is '''N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)'''. Other names in common use include '''lysine-2-oxoglutarate reductase''', '''dehydrogenase, saccharopine (nicotinamide adenine dinucleotide,''', '''lysine forming)''', '''epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine''', '''forming)''', '''N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)''', '''6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase''', and '''(L-lysine-forming)'''This enzyme participates in [[lysine biosynthesis]] and [[lysine degradation]].
 
==Structural studies==
 
As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1FF9}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Fujioka M, Nakatani Y | date = 1972 | title = Saccharopine dehydrogenase. Interaction with substrate analogues | journal = Eur. J. Biochem. | volume = 25 | pages = 301&ndash;7  | pmid = 4339117 | doi = 10.1111/j.1432-1033.1972.tb01697.x | issue = 2 }}
* {{cite journal | author = Saunders PP, Broquist HP | date = 1966 | title = Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase | journal = J. Biol. Chem. | volume = 241 | pages = 3435&ndash;40  | pmid = 4287986 | issue = 14 }}
 
{{1.5-enzyme-stub}}
 
[[Category:EC 1.5.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of known structure]]

Latest revision as of 03:58, 2 March 2013

Template:Enzyme In enzymology, a saccharopine dehydrogenase (NAD+, L-lysine-forming) (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O L-lysine + 2-oxoglutarate + NADH + H+

The 3 substrates of this enzyme are N6-(L-1,3-dicarboxypropyl)-L-lysine, NAD+, and H2O, whereas its 4 products are L-lysine, 2-oxoglutarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming). Other names in common use include lysine-2-oxoglutarate reductase, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide,, lysine forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine, forming), N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming), 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase, and (L-lysine-forming). This enzyme participates in lysine biosynthesis and lysine degradation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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Template:1.5-enzyme-stub