Cucurbitacin Delta23-reductase: Difference between revisions
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{{enzyme | |||
| Name = dihydrouracil dehydrogenase (NAD+) | |||
| EC_number = 1.3.1.1 | |||
| CAS_number = 9026-89-5 | |||
| IUBMB_EC_number = 1/3/1/1 | |||
| GO_code = 0004159 | |||
| image = | |||
| width = | |||
| caption = | |||
}} | |||
{{verify|date=April 2011}} | |||
In [[enzymology]], a '''dihydrouracil dehydrogenase (NAD+)''' ({{EC number|1.3.1.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] | |||
:5,6-dihydrouracil + NAD<sup>+</sup> <math>\rightleftharpoons</math> uracil + NADH + H<sup>+</sup> | |||
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[5,6-dihydrouracil]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[uracil]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]]. | |||
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is '''5,6-dihydrouracil:NAD+ oxidoreductase'''. Other names in common use include '''dehydrogenase, dihydrouracil''', '''dihydropyrimidine dehydrogenase''', '''dihydrothymine dehydrogenase''', '''pyrimidine reductase''', '''thymine reductase''', '''uracil reductase''', and '''dihydrouracil dehydrogenase (NAD+)'''. This enzyme participates in 3 [[metabolism|metabolic pathways]]: [[pyrimidine metabolism]], [[beta-alanine metabolism]], and [[pantothenate and coa biosynthesis]]. | |||
==References== | |||
{{reflist|1}} | |||
* {{cite journal | author = CAMPBELL LL Jr | date = 1957 | title = Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase | journal = J. Biol. Chem. | volume = 227 | pages = 693–700 | pmid = 13462991 | issue = 2 }} | |||
{{1.3-enzyme-stub}} | |||
[[Category:EC 1.3.1]] | |||
[[Category:NADH-dependent enzymes]] | |||
[[Category:Enzymes of unknown structure]] | |||
Revision as of 03:43, 2 March 2013
Template:Enzyme
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Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NAD+, whereas its 3 products are uracil, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6-dihydrouracil:NAD+ oxidoreductase. Other names in common use include dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, pyrimidine reductase, thymine reductase, uracil reductase, and dihydrouracil dehydrogenase (NAD+). This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.
References
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