Mannitol-1-phosphatase: Difference between revisions

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{{enzyme
| Name = N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
| EC_number = 3.1.4.45
| CAS_number = 75788-84-0
| IUBMB_EC_number = 3/1/4/45
| GO_code = 0003944
| image =
| width =
| caption =
}}
In [[enzymology]], a '''N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase''' ({{EC number|3.1.4.45}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H<sub>2</sub>O <math>\rightleftharpoons</math> N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose


Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[N-acetyl-D-glucosamine]] and [[glycoprotein phospho-D-mannose]].
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This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on phosphoric [[ester|diester]] bonds. The systematic name of this enzyme class is '''glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase'''. Other names in common use include '''alpha-N-acetylglucosaminyl phosphodiesterase''', '''lysosomal alpha-N-acetylglucosaminidase''', '''phosphodiester glycosidase''', '''alpha-N-acetyl-D-glucosamine-1-phosphodiester''', '''N-acetylglucosaminidase''', '''2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester''', and '''acetamidodeoxyglucohydrolase'''.
 
==References==
{{reflist|1}}
* {{cite journal | author = Probst C, Grotz M, Krettek C, Pape HC | date = 2005 | title = Impact of hypothermia on the immunologic response after trauma and elective surgery | journal = Surg. Technol. Int.  | volume = 14 | pages = 41&ndash;50  | pmid = 16525953 }}
* {{cite journal | author = van der Drift C, van Helvoort PE, Vogels GD | date = 1971 | title = S-ureidoglycolate dehydrogenase: purification and properties | journal = Arch. Biochem. Biophys.  | volume = 145 | pages = 465&ndash;9  | pmid = 4399430 | doi = 10.1016/S0003-9861(71)80006-1 | issue = 2 }}
* {{cite journal | author = Van der Drift L, Vogels GD, Van der Drift C | date = 1975 | title = Allantoin racemase: a new enzyme from Pseudomonas species | journal = Biochim. Biophys. Acta. | volume = 391 | pages = 240&ndash;8  | pmid = 237557 | issue = 1 }}
* {{cite journal | author = Waheed A, Hasilik A, von Figura K | date = 1981 | title = Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase | journal = J. Biol. Chem. | volume = 256 | pages = 5717&ndash;21  | pmid = 6263889 | issue = 11 }}
 
{{hydrolase-stub}}
 
[[Category:EC 3.1.4]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 08:11, 17 May 2014


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