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| {{enzyme
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| | Name = methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing)
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| | EC_number = 2.1.1.74
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| | CAS_number = 74665-78-4
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| | IUBMB_EC_number = 2/1/1/74
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| | GO_code = 0047151
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| In [[enzymology]], a '''methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase''' ({{EC number|2.1.1.74}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH<sub>2</sub> <math>\rightleftharpoons</math> tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[5,10-methylenetetrahydrofolate]], [[tRNA containing uridine at position 54]], and [[FADH2]], whereas its 3 [[product (chemistry)|products]] are [[tetrahydrofolate]], [[tRNA containing ribothymidine at position 54]], and [[FAD]].
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| This enzyme belongs to the family of [[transferase]]s, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is '''5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyl-transferase'''. Other names in common use include '''(FADH2-oxidizing)''', '''folate-dependent ribothymidyl synthase''', '''methylenetetrahydrofolate-transfer ribonucleate uracil''', '''5-methyltransferase''', '''5,10-methylenetetrahydrofolate:tRNA-UPsiC''', and '''(uracil-5-)-methyl-transferase'''.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Delk AS, Nagle DP Jr, Rabinowitz JC | year = 1980 | title = Methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer RNA of Streptococcus faecalis. Evidence for reduction of the 1-carbon unit by FADH2 | journal = J. Biol. Chem. | volume = 255 | pages = 4387–90 | pmid = 6768721 | issue = 10 }}
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| * {{cite journal | author = Becker HF, Motorin Y, Sissler M, Florentz C, Grosjean H | year = 1997 | title = Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T psi-loop of yeast tRNAs | journal = J. Mol. Biol. | volume = 274 | pages = 505–18 | pmid = 9417931 | doi = 10.1006/jmbi.1997.1417 | issue = 4 }}
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| {{DEFAULTSORT:Methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase}}
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| [[Category:EC 2.1.1]] | |
| [[Category:Enzymes of unknown structure]]
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| {{transferase-stub}}
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