Sepiapterin reductase: Difference between revisions

From formulasearchengine
Jump to navigation Jump to search
en>Monkbot
en>Rjwilmsi
m →Further reading: Added 1 doi to a journal cite using AWB (10216)
 
Line 1: Line 1:
{{enzyme
== Athi Nangamso Esther Nkopo ==
| Name = testosterone 17-beta-dehydrogenase (NAD<sup>+</sup>)
| EC_number = 1.1.1.63
| CAS_number = 9028-62-0
| IUBMB_EC_number = 1/1/1/63
| GO_code = 0050327
| image =
| width =
| caption =
}}
{{enzyme
| Name = testosterone 17-beta-dehydrogenase (NADP<sup>+</sup>)
| EC_number = 1.1.1.64
| CAS_number = 9028-63-1
| IUBMB_EC_number = 1/1/1/64
| GO_code = 0047045
| image =
| width =
| caption =
}}
In [[enzymology]], a '''testosterone 17beta-dehydrogenase''' is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] between [[testosterone]] and [[androst-4-ene-3,17-dione]].


This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''17beta-hydroxysteroid:NAD<sup>+</sup> 17-oxidoreductase'''. Other names in common use include '''17-ketoreductase''', and '''17beta-HSD'''. This enzyme participates in [[androgen and estrogen metabolism]].
As Carl Weathers told Stallone within Rocky III, is no the day after tomorrow! I wanted under four hours, we wanted it bad. This is primarily because we come to associate a full head of hair with virility. Less comical is the fact that a United States Senator has been told by the Intelligence Community what he can and cannot claim. <br><br>Athi Nangamso Esther Nkopo, Andile Mngxitama: There's no unlearning whiteness, despite what 'anti racists' say"[In America] stop racism by whites became exposed as sophisticated bias. That did not mean he is an undesirable sign language interpreter.". Westminster and the press are still dominated by the idea that if staff members' representatives seek to influence state policies they must be bullies; while if capitalists manage to get thier way, then that's without doubt good for capitalism. <br><br>(And, oh: likely spoiler alerts ahead.). He opened up the door for black music. Local campaigners and the Civic Confidence asked Ed Vaizey to use his / her legal powers to intervene. Mac tend to be pricier since they're higher quality and last longer. Louis Jazz while filling into McQuaid's location in a bottom defensemen pairing with Torey Krug. <br><br>A new study by Douglas Mental Wellness University Institute researchers has demonstrated that low melatonin levels lead to premenstrual dysphoric disorder (PMDD), or good old fashioned PMS. It is just a major milestone for Michael Jackson's growing postmortem business empire, primarily considering where the estate started off. <br><br>The government then needs to "make confident the institutions are suitable, so enforcing laws, prosecuting people who make bad options or [who] corrupt community funds".. Nonetheless, the National Crime Records Institution reports that in 2011, Delhi NCT has a 41.5 per cent conviction rate in rape circumstances compared to the 26.4 percentage national conviction rate. <br><br>However, like all democracies, it's incredibly hard work  enormously costly to be here, to locate a space to perform in plus live in and to promote your efficiency. It is quite common for people for you to confuse sexual preference by using gender identity. As I brought up, trade shows are pricey, so it will be important to pick the right ones. <br><br>Chemicals are released and then need to be identified by another molecule, any receptor, for their signal to be successfully transmitted. I like very much to manufacture a space to showcase these events, but first, I need to see what tools are available to us after the relaunch.. <br><br>And because we not much of a breaking news site and because we write with reflection and with greater detail, sixty less immediate. Unbowed, the libertarian bending conservatives, tea partiers and liberal Democrats who led the fight explained they will try to undo a program they called an unconstitutional intrusion on civil liberties..<ul>
 
 
==Variants==
  <li>[http://www.middleeasttransparent.com/spip.php?article9467&lang=ar&id_forum=10581/ http://www.middleeasttransparent.com/spip.php?article9467&lang=ar&id_forum=10581/]</li>
There are two variants of the enzyme, one that uses [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]] as a substrate, and one that uses [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]] as acceptor.
 
 
  <li>[http://cgi.www5f.biglobe.ne.jp/~maihani/apeboard_plus3.cgi/ http://cgi.www5f.biglobe.ne.jp/~maihani/apeboard_plus3.cgi/]</li>
===NAD<sup>+</sup>===
 
This variant of testosterone 17beta-dehydrogenase ({{EC number|1.1.1.63}}) catalyzes the reaction
  <li>[http://www.imc-e.net/thread-2820421-1-1.html http://www.imc-e.net/thread-2820421-1-1.html]</li>
 
 
:testosterone + NAD<sup>+</sup> <math>\rightleftharpoons</math> androst-4-ene-3,17-dione + NADH + H<sup>+</sup>
  <li>[http://havocgamerzz.freeiz.com/index.php?site=news_comments&newsID=5 http://havocgamerzz.freeiz.com/index.php?site=news_comments&newsID=5]</li>
 
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[testosterone]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[androst-4-ene-3,17-dione]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
  <li>[http://ldsbee.com/index.php?page=item&id=4120467 http://ldsbee.com/index.php?page=item&id=4120467]</li>
 
 
===NADP<sup>+</sup>===
</ul>
This variant of testosterone 17beta-dehydrogenase ({{EC number|1.1.1.64}}) catalyzes the reaction
 
:testosterone + NADP<sup>+</sup> <math>\rightleftharpoons</math> androst-4-ene-3,17-dione + NADPH + H<sup>+</sup>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[testosterone]] and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[androst-4-ene-3,17-dione]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Endahl GL, Kochakian CD, Hamm D | date = 1960 | title = Separation of a Triphosphopyridine Nucleotide-specific from a Diphosphopyridine Nucleotide-specific 17''β''-Hydroxy-(testosterone)dehydrogenase of Guinea Pig Liver | journal = J. Biol. Chem. | volume = 235 | pages = 2792&ndash;6 | pmid = 13696735 }}
* {{cite journal | author = Sweat ML, Samuels LT, Lumry R | date = 1950 | title = Preparation and haracterization of the enzyme which converts testosterone to androstenedione | journal = J. Biol. Chem. | volume = 185 | pages = 75&ndash;84 | pmid = 15436478 | issue = 1 }}
* {{cite journal | author = Villee CA and Spencer JM | date = 1960 | title = Some Properties of the Pyridine Nucleotide-specific 17''β''-Hydroxy Steroid Dehydrogenases of Guinea Pig Liver | journal = J. Biol. Chem. | volume = 235 | pages = 3615&ndash;3619 | pmid=13781425}}
 
[[Category:EC 1.1.1]]
[[Category:NADH-dependent enzymes]]
[[Category:NADPH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]
[[Category:Enzymes of known structure]]
[[Category:Testosterone]]
 
 
{{1.1.1-enzyme-stub}}

Latest revision as of 17:26, 1 June 2014

Athi Nangamso Esther Nkopo

As Carl Weathers told Stallone within Rocky III, is no the day after tomorrow! I wanted under four hours, we wanted it bad. This is primarily because we come to associate a full head of hair with virility. Less comical is the fact that a United States Senator has been told by the Intelligence Community what he can and cannot claim.

Athi Nangamso Esther Nkopo, Andile Mngxitama: There's no unlearning whiteness, despite what 'anti racists' say"[In America] stop racism by whites became exposed as sophisticated bias. That did not mean he is an undesirable sign language interpreter.". Westminster and the press are still dominated by the idea that if staff members' representatives seek to influence state policies they must be bullies; while if capitalists manage to get thier way, then that's without doubt good for capitalism.

(And, oh: likely spoiler alerts ahead.). He opened up the door for black music. Local campaigners and the Civic Confidence asked Ed Vaizey to use his / her legal powers to intervene. Mac tend to be pricier since they're higher quality and last longer. Louis Jazz while filling into McQuaid's location in a bottom defensemen pairing with Torey Krug.

A new study by Douglas Mental Wellness University Institute researchers has demonstrated that low melatonin levels lead to premenstrual dysphoric disorder (PMDD), or good old fashioned PMS. It is just a major milestone for Michael Jackson's growing postmortem business empire, primarily considering where the estate started off.

The government then needs to "make confident the institutions are suitable, so enforcing laws, prosecuting people who make bad options or [who] corrupt community funds".. Nonetheless, the National Crime Records Institution reports that in 2011, Delhi NCT has a 41.5 per cent conviction rate in rape circumstances compared to the 26.4 percentage national conviction rate.

However, like all democracies, it's incredibly hard work enormously costly to be here, to locate a space to perform in plus live in and to promote your efficiency. It is quite common for people for you to confuse sexual preference by using gender identity. As I brought up, trade shows are pricey, so it will be important to pick the right ones.

Chemicals are released and then need to be identified by another molecule, any receptor, for their signal to be successfully transmitted. I like very much to manufacture a space to showcase these events, but first, I need to see what tools are available to us after the relaunch..

And because we not much of a breaking news site and because we write with reflection and with greater detail, sixty less immediate. Unbowed, the libertarian bending conservatives, tea partiers and liberal Democrats who led the fight explained they will try to undo a program they called an unconstitutional intrusion on civil liberties..