Multiple trace theory: Difference between revisions

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{{enzyme
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| Name = channel-conductance-controlling ATPase
| EC_number = 3.6.3.49
| CAS_number =
| IUBMB_EC_number = 3/6/3/49
| GO_code = 0005260
| image =
| width =
| caption =
}}
In [[enzymology]], a '''channel-conductance-controlling ATPase''' ({{EC number|3.6.3.49}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + H<sub>2</sub>O <math>\rightleftharpoons</math> ADP + phosphate
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[phosphate]].
 
This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is '''ATP phosphohydrolase (channel-conductance-controlling)'''.  
 
==Structural studies==
 
As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1XMI}} and {{PDB link|1XMJ}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Chen M, Zhang JT | year = 1996 | title = Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes | journal = Mol. Membr. Biol. | volume = 13 | pages = 33&ndash;40  | pmid = 9147660 | doi = 10.3109/09687689609160572 | issue = 1 }}
* {{cite journal | author = Tusnady GE, Bakos E, Varadi A, Sarkadi B | year = 1997 | title = Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters | journal = FEBS. Lett. | volume = 402 | pages = 1&ndash;3  | pmid = 9013845 | doi = 10.1016/S0014-5793(96)01478-0 | issue = 1 }}
* {{cite journal | author = Sheppard DN, Welsh MJ | year = 1999 | title = Structure and function of the CFTR chloride channel | journal = Physiol. Rev. | volume = 79 | pages = S23&ndash;45  | pmid = 9922375 | issue = 1 Suppl }}
 
[[Category:EC 3.6.3]]
[[Category:Enzymes of known structure]]
 
 
{{hydrolase-stub}}

Latest revision as of 13:52, 18 July 2014

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