|
|
| Line 1: |
Line 1: |
| {{enzyme
| | Hello from Germany. I'm glad to came across you. My first name is Kandice. <br>I live in a town called Badenheim in western Germany.<br>I was also born in Badenheim 28 years ago. Married in September year 2002. I'm working at the university.<br><br>My web blog [http://tinyurl.com/lg86kzh Celine Handbags UK Outlet] |
| | Name = pyrroline-5-carboxylate reductase
| |
| | EC_number = 1.5.1.2
| |
| | CAS_number = 9029-17-8
| |
| | IUBMB_EC_number = 1/5/1/2
| |
| | GO_code = 0004735
| |
| | image =
| |
| | width =
| |
| | caption =
| |
| }}
| |
| In [[enzymology]], a '''pyrroline-5-carboxylate reductase''' ({{EC number|1.5.1.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
| |
| | |
| :L-proline + NAD(P)+ <math>\rightleftharpoons</math> 1-pyrroline-5-carboxylate + NAD(P)H + H<sup>+</sup>
| |
| | |
| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[L-proline]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[1-Pyrroline-5-carboxylic acid|1-pyrroline-5-carboxylate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
| |
| | |
| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is '''L-proline:NAD(P)+ 5-oxidoreductase'''. Other names in common use include '''proline oxidase''', '''L-proline oxidase''', '''1-pyrroline-5-carboxylate reductase''', '''NADPH-L-Delta1-pyrroline carboxylic acid reductase''', and '''L-proline-NAD(P)+ 5-oxidoreductase'''. This enzyme participates in [[arginine]] and [[proline]] metabolism.
| |
| | |
| ==Structural studies==
| |
| | |
| As of late 2007, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2AHR}}, {{PDB link|2GER}}, {{PDB link|2GR9}}, {{PDB link|2GRA}}, and {{PDB link|2IZZ}}.
| |
| | |
| ==References==
| |
| {{reflist|1}}
| |
| * {{cite journal | author = Adams E and Goldstone A | year = 1960 | title = Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta1-pyrroline-3-hydroxy-5-carboxylate | journal = J. Biol. Chem. | volume = 235 | pages = 3499–3503 }}
| |
| * {{cite journal | author = Meister A, Radhakrishnan AN and Buckley SD | year = 1957 | title = Enzymatic synthesis of L-pipecolic acid and L-proline | journal = J. Biol. Chem. | volume = 229 | issue = 2 | pages = 789–800 | pmid=13502341}}
| |
| * {{cite journal | author = Smith ME and Greenberg DM | date = Lond. | title = Characterization of an enzyme reducing pyrroline-5-carboxylate to proline | journal = N | volume = Nature | pages = 1130 }}
| |
| * {{cite journal | author = Yura T and Vogel HJ | year = 1959 | title = Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties | journal = J. Biol. Chem. | volume = 234 | pages = 335–338 }}
| |
| | |
| {{Amino acid metabolism enzymes}}
| |
| | |
| [[Category:EC 1.5.1]] | |
| [[Category:NADPH-dependent enzymes]]
| |
| [[Category:NADH-dependent enzymes]]
| |
| [[Category:Enzymes of known structure]]
| |
| | |
| | |
| {{1.5-enzyme-stub}}
| |
Hello from Germany. I'm glad to came across you. My first name is Kandice.
I live in a town called Badenheim in western Germany.
I was also born in Badenheim 28 years ago. Married in September year 2002. I'm working at the university.
My web blog Celine Handbags UK Outlet