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en>Plastikspork: Margin
2013-11-18T00:15:27Z
<p>Margin</p>
<p><b>New page</b></p><div>{{Infobox enzyme<br />
| Name = Cholesterol-5,6-oxide hydrolase<br />
| EC_number = 3.3.2.11<br />
| CAS_number = <br />
| IUBMB_EC_number = 3/3/2/11<br />
| GO_code = <br />
| image = <br />
| width = <br />
| caption =<br />
}}<br />
'''Cholesterol-5,6-oxide hydrolase''' ({{EC number|3.3.2.11}}, ''cholesterol-epoxide hydrolase'', ''ChEH'') is an [[enzyme]] with system name ''5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase''.<ref>{{cite journal | title = Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 &alpha;-oxide and certain xenobiotic alkene and arene oxides |author = Levin, W., Michaud, D.P., Thomas, P.E. and Jerina, D.M. |journal = Arch. Biochem. Biophys. |year = 1983 |volume = 220 |pages = 485–494 |pmid = 6401984}}</ref><ref>{{cite journal | title = Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities |author = Oesch, F., Timms, C.W., Walker, C.H., Guenthner, T.M., Sparrow, A., Watabe, T. and Wolf, C.R. |journal = Carcinogenesis |year = 1984 |volume = 5 |pages = 7–9 |pmid = 6690087}}</ref><ref>{{cite journal | title = Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase |author = Sevanian, A. and McLeod, L.L. |journal = J. Biol. Chem. |year = 1986 |volume = 261 |pages = 54–59 |pmid = 3941086}}</ref><ref>{{cite journal | title = Epoxide hydrolases: biochemistry and molecular biology |author = Fretland, A.J. and Omiecinski, C.J. |journal = Chem. Biol. Interact. |year = 2000 |volume = 129 |pages = 41–59 |pmid = 11154734 |doi=10.1016/S0009-2797(00)00197-6}}</ref><ref>{{cite journal | title = Epoxide hydrolases: their roles and interactions with lipid metabolism |author = Newman, J.W., Morisseau, C. and Hammock, B.D. |journal = Prog. Lipid Res. |year = 2005 |volume = 44 |pages = 1–51 |pmid = 15748653 |doi=10.1016/j.plipres.2004.10.001}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<br />
<br />
: (1) 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H<sub>2</sub>O <math>\rightleftharpoons</math> 5alpha-cholestane-3beta,5alpha,6beta-triol<br />
: (2) 5,6beta-epoxy-5beta-cholestan-3beta-ol + H<sub>2</sub>O <math>\rightleftharpoons</math> 5alpha-cholestane-3beta,5alpha,6beta-triol<br />
<br />
The enzyme works equally well with either [[epoxide]] as substrate.<br />
<br />
== References ==<br />
{{reflist}}<br />
<br />
== External links ==<br />
* {{MeshName|+cholesterol-5,6-oxide+hydrolase}}<br />
<br />
[[Category:EC 3.3.2]]</div>
en>Plastikspork