Monodehydroascorbate reductase (NADH) - Revision history

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			\| Name = NADPH dehydrogenase (quinone)
			\| EC_number = 1.6.5.10
			\| CAS_number = 37256-37-4
			\| IUBMB_EC_number = 1/6/5/10
			\| GO_code = 0008753
			\| image =
			\| width =
			\| caption =
			}}
			In [[enzymology]], a '''NADPH dehydrogenase (quinone)''' ({{EC number\|1.6.5.10}}) is an [[enzyme]] that [[catalysis\|catalyzes]] the [[chemical reaction]]

			:NADPH + H<sup>+</sup> + acceptor <math>\rightleftharpoons</math> NADP<sup>+</sup> + reduced acceptor

			The 3 [[substrate (biochemistry)\|substrates]] of this enzyme are [[nicotinamide adenine dinucleotide phosphate\|NADPH]], [[hydrogen ion\|H<sup>+</sup>]], and [[Electron acceptor\|acceptor]], whereas its two [[product (chemistry)\|products]] are [[nicotinamide adenine dinucleotide phosphate\|NADP<sup>+</sup>]] and [[reduced acceptor]].

			This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is '''NADPH:(quinone-acceptor) oxidoreductase'''. Other names in common use include '''reduced nicotinamide adenine dinucleotide phosphate (quinone)''', '''dehydrogenase''', '''NADPH oxidase''', and '''NADPH2 dehydrogenase (quinone)'''. It has 2 [[cofactor (biochemistry)\|cofactors]]: [[FAD]], and [[Flavoprotein]]. Several compounds are known to [[enzyme inhibitor\|inhibit this enzyme]], including [[Folate]], and [[Dicumarol]].

			==Structural studies==
			As of late 2007, only one [[tertiary structure\|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank\|PDB]] accession code {{PDB link\|1F5V}}.

			== See also ==
			* [[NdhF]]

			==References==
			{{reflist\|1}}
			* {{cite journal \| author = Koli AK, Yearby C, Scott W, Donaldson KO \| date = 1969 \| title = Purification and properties of three separate menadione reductases from hog liver \| journal = J. Biol. Chem. \| volume = 244 \| pages = 621–9 \| pmid = 4388793 \| issue = 4 }}

			{{1.6-enzyme-stub}}

			[[Category:EC 1.6.5]]
			[[Category:NADPH-dependent enzymes]]
			[[Category:Flavin enzymes]]
			[[Category:Flavoprotein enzymes]]
			[[Category:Enzymes of known structure]]

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