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Michigan Spin Physics Center - Revision history
2026-08-17T08:21:32Z
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en>Suslindisambiguator at 17:36, 5 January 2014
2014-01-05T17:36:39Z
<p></p>
<p><b>New page</b></p><div>{{Infobox enzyme<br />
| Name = Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase<br />
| EC_number = 2.4.1.144<br />
| CAS_number = 83744-93-8<br />
| IUBMB_EC_number = 2/4/1/144<br />
| GO_code = <br />
| image = <br />
| width = <br />
| caption =<br />
}}<br />
'''Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase''' ({{EC number|2.4.1.144}}, ''N-acetylglucosaminyltransferase III'', ''N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III'', ''uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III'', ''beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase'', ''GnTIII'') is an [[enzyme]] with system name ''UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase''.<ref>{{cite journal | title = Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide &beta;4-''N''-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in &beta;1-4 linkage to the &beta;-linked mannose of the trimannosyl core of ''N''-glycosyl oligosaccharides |author = Narasimhan, S. |journal = J. Biol. Chem. |year = 1982 |volume = 257 |pages = 10235–10242 |pmid = 6213618 |issue=17}}</ref><ref>{{cite journal | title = Glycosyltransferases involved in elongation of ''N''-glycosidically linked oligosaccharides of the complex or ''N''-acetyllactosamine type |author = Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. |journal = Methods Enzymol. |year = 1983 |volume = 98 |pages = 98–134 |pmid = 6366476 |doi=10.1016/0076-6879(83)98143-0}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<br />
<br />
: [[UDP-N-acetyl-D-glucosamine]] + beta-D-mannosyl-R <math>\rightleftharpoons</math> UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R<br />
<br />
R represents the remainder of the N-linked [[oligosaccharide]] in the [[glycoprotein]] acceptor.<br />
<br />
== References ==<br />
{{reflist}}<br />
<br />
== External links ==<br />
* {{MeshName|Beta-1,4-mannosyl-glycoprotein+4-beta-N-acetylglucosaminyltransferase}}<br />
<br />
[[Category:EC 2.4.1]]</div>
en>Suslindisambiguator