en>Galizur at 04:23, 29 December 2013

2013-12-29T04:23:18Z

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{{Infobox enzyme
| Name = Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
| EC_number = 2.4.1.143
| CAS_number = 105913-04-0
| IUBMB_EC_number = 2/4/1/143
| GO_code =
| image =
| width =
| caption =
}}
'''Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase''' ({{EC number|2.4.1.143}}, ''N-acetylglucosaminyltransferase II'', ''N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II'', ''acetylglucosaminyltransferase II'', ''uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase'', ''uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase'', ''uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase'', ''UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase'', ''alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase'', ''GnTII'') is an [[enzyme]] with system name ''UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase''.<ref>{{cite journal | title = Control of glycoprotein synthesis. Purification of UDP-''N''-acetylglucosamine:α-D-mannoside β1-2 ''N''-acetylglucosaminyltransferase II from rat liver |author = Bendiak, B. and Schacter, H. |journal = J. Biol. Chem. |year = 1987 |volume = 262 |pages = 5775–5783 |pmid = 2952644 |issue=12}}</ref><ref>{{cite journal | title = Control of glycoprotein synthesis. Bovine colostrum UDP-''N''-acetylglucosamine:α-D-mannoside β2-''N''-acetylglucosaminyltransferase I. Separation from UDP-''N''-acetylglucosamine:α-D-mannoside β2-''N''-acetylglucosaminyltransferase II, partial purification, and substrate specificity |author = Harpaz, N. and Schachter, H. |journal = J. Biol. Chem. |year = 1980 |volume = 255 |pages = 4885–4893 |pmid = 6445358 |issue=10}}</ref><ref>{{cite journal | title = Isolation and properties of α-D-mannose:β-1,2-''N''-acetylglucosaminyltransferase from trachea mucosa |author = Mendicino, J., Chandrasekaran, E.V., Anumula, K.R. and Davila, M. |journal = Biochemistry |year = 1981 |volume = 20 |pages = 967–976 |pmid = 6452163 |issue=4}}</ref><ref>{{cite journal | title = The nonidentity of porcine ''N''-acetylglucosaminyltransferases I and II |author = Oppenheimer, C.L., Eckhardt, A.E. and Hill, R.L. |journal = J. Biol. Chem. |year = 1981 |volume = 256 |pages = 11477–11482 |pmid = 6457827 |issue=22}}</ref><ref>{{cite journal | title = Glycosyltransferases involved in elongation of ''N''-glycosidically linked oligosaccharides of the complex or ''N''-acetyllactosamine type |author = Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. |journal = Methods Enzymol. |year = 1983 |volume = 98 |pages = 98–134 |pmid = 6366476 |doi=10.1016/0076-6879(83)98143-0}}</ref><ref>{{cite journal | title = Control of glycoprotein synthesis. Kinetic mechanism, substrate specificity, and inhibition characteristics of UDP-''N''-acetylglucosamine:α-D-mannoside β-1-2 ''N''-acetylglucosaminyltransferase II from rat liver |author = Bendiak, B. and Schachter, H. |journal = J. Biol. Chem. |year = 1987 |volume = 262 |pages = 5784–5790 |pmid = 2952644 |issue=12}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[UDP-N-acetyl-D-glucosamine]] + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R <math>\rightleftharpoons</math> UDP + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

R represents the remainder of the N-linked [[oligosaccharide]] in the [[glycoprotein]] acceptor.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Alpha-1,6-mannosyl-glycoprotein+2-beta-N-acetylglucosaminyltransferase}}

[[Category:EC 2.4.1]]

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en>Galizur at 04:23, 29 December 2013