en>Fgnievinski: /* See also */

2014-07-13T03:26:44Z

See also

← Older revision		Revision as of 05:26, 13 July 2014
Line 1:		Line 1:
	~~{{merge from\|Defined daily dose\|date=January 2012}}~~		All shops no matter how big they are make a [http://www.charlie911.com/uggboots.html discount ugg boots] every year. They may make it once a year or more frequent. When you are in store, ask a [https://www.gov.uk/search?q=manager manager] when they are planning to hold the next sale. [http://www.charlie911.com/uggboots.html discount ugg boots] It might be a good idea to wait for it instead of buying now. People often start thinking [http://www.charlie911.com/uggboots.html ugg boots outlet] about new boots either before or at the end of the winter season. So' they don't need them just at that time. So, it will be better to wait until [http://www.charlie911.com/uggboots.html ugg boots outlet] you find them for cheap.<br>There are often some models or the colors in the shop that cost cheaper than other types of boots. So, should [http://www.charlie911.com/uggboots.html http://www.charlie911.com/uggboots.html] we look at UGG types that aren't very fashionable and popular? If no, that you are making mistakes. These offers are much cheaper than the medium ones.<br>Don't forget about internet and look for good offers in online stores too. Besides some of them create sales too, so you may find really cheap boots. Just make some quick research using Google. Some of the stores on the internet are selling fakes, so if the price is just too low, it might be a bad offer.<br>As you see, anybody can find cheap UGG boots. It is the problem of time and luck. To be true, if somebody from your friends is wearing UGG boots, he probably has bought them for cheap too.<br>The materials in the boots is impressive. They can be leather or suede, which would love to own. You simply need to ask the specifications and will probably be at your door. Let me let you know, the company is offering free delivery on all boots Greatest and this really is your likelihood to obtain his boots shipped totally free. Additionally, the lining with the boots of women's style UGG is actually created of skin, so that the height of style UGG boots to become even more comfortable. Nonetheless, style UGG boots are a great purchase, as they're quite comfortable and keep your feet warm successfully. That is the entire level from the buy of very hot boots. Nevertheless, if you're looking for style then you can also decide on these women boots.<br><br>Author Bio io
	~~A '''maintenance dose''' is the maintenance rate~~ [mg/h] ~~of drug administration equal to the rate of elimination at steady state~~. ~~This is not to be confused with~~ a ~~dose regimen~~, ~~which is~~ a ~~type of drug therapy in which the~~ [~~[dosing\|dose]~~] [mg] of a [~~[drug~~]~~] is given~~ at ~~a regular dosing interval on a repetitive basis. Continuing~~ the ~~maintenance dose for about 4 to 5 [[half life\|half lives]] (t<sub>½</sub>)~~ of the ~~drug~~ will ~~approximate the~~ [~~[pharmacokinetics\|steady state]] level.<ref>{{cite book \|last1= Houglum\|first1= Joel \|authorlink1= \|last2= Harrelson\|first2= Gary \|title= Principles of Pharmacology for Athletic Trainers\|url=~~ http://~~books~~.~~google~~.com/~~books?id=wbkoeZuwqjwC\|accessdate= 2012-01-26\|type= \|year= 2010\|publisher= SLACK Incorporated\|isbn= 1-55642-901-0\|page=51}}~~<~~/ref~~> ~~One~~ or ~~more doses higher than~~ the ~~maintenance dose can be given together at~~ the ~~beginning~~ of ~~therapy with a~~ [~~[loading dose]].<ref name="urlCp vs time - iv infusion with loading dose">{{cite web \|url=~~http://www.~~chm~~.~~davidson~~.~~edu~~/~~erstevens~~/~~iv%20load%20Cp%20v%20t~~/~~iv%20load%20Cp%20v%20t~~.html ~~\|title=Cp vs time - iv infusion with loading dose \|work= \|accessdate=}}</ref>~~

	~~A loading dose is most useful for drugs~~ that are ~~[[Clearance (medicine)\|eliminated from~~ the ~~body]] relatively slowly~~. ~~Such drugs need only a low maintenance dose~~ in ~~order to keep the amount~~ of the ~~drug in~~ the ~~body at~~ the ~~appropriate level, but this also means that, without an initial higher dose~~, it ~~would take~~ a ~~long time for~~ the ~~amount~~ of ~~the drug in the body to reach that level~~.

	~~== Calculating the maintenance dose ==~~

	~~The required maintenance dose may~~ be ~~calculated as:~~

	~~:<math>\mbox{MD} = \frac{C_p CL}{F }</math>~~

	~~Where:~~
	~~:{\|~~
	~~\| ''MD'' \|\|~~ is ~~the maintenance dose rate [mg/h]~~
	\|-
	~~\| ''C~~<~~sub~~>~~p</sub>'' \|\| = desired peak [[concentration]] of drug [mg/L]~~
	\|-
	~~\| ''CL'' \|\| = [[Clearance (medicine)\|clearance]] of drug~~ in ~~body [L/h]~~
	\|-
	~~\| ''F'' \|\| = [[bioavailability]]~~
	\|}

	~~For an intravenously administered drug~~, the ~~bioavailability ''F''~~ will ~~equal 1~~, ~~since~~ the ~~drug~~ is ~~directly introduced~~ to the ~~bloodstream. If~~ the ~~patient requires an oral dose~~, ~~bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc~~.), ~~requiring~~ a ~~larger loading dose~~.

	~~== See~~ also ==
	* [[Therapeutic index]]

	~~==References==~~
	~~{{reflist}}~~

	~~{{Pharmacology}}~~

	~~[[Category:Pharmacology]]~~


	~~{{pharma-stub}}~~

en>Tony1 at 13:01, 22 July 2012

2012-07-22T13:01:08Z

New page

{{merge from|Defined daily dose|date=January 2012}}
A '''maintenance dose''' is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with a dose regimen, which is a type of drug therapy in which the [[dosing|dose]] [mg] of a [[drug]] is given at a regular dosing interval on a repetitive basis. Continuing the maintenance dose for about 4 to 5 [[half life|half lives]] (t<sub>½</sub>) of the drug will approximate the [[pharmacokinetics|steady state]] level.<ref>{{cite book |last1= Houglum|first1= Joel |authorlink1= |last2= Harrelson|first2= Gary |title= Principles of Pharmacology for Athletic Trainers|url= http://books.google.com/books?id=wbkoeZuwqjwC|accessdate= 2012-01-26|type= |year= 2010|publisher= SLACK Incorporated|isbn= 1-55642-901-0|page=51}}</ref> One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a [[loading dose]].<ref name="urlCp vs time - iv infusion with loading dose">{{cite web |url=http://www.chm.davidson.edu/erstevens/iv%20load%20Cp%20v%20t/iv%20load%20Cp%20v%20t.html |title=Cp vs time - iv infusion with loading dose |work= |accessdate=}}</ref>

A loading dose is most useful for drugs that are [[Clearance (medicine)|eliminated from the body]] relatively slowly. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate level, but this also means that, without an initial higher dose, it would take a long time for the amount of the drug in the body to reach that level.

== Calculating the maintenance dose ==

The required maintenance dose may be calculated as:

:<math>\mbox{MD} = \frac{C_p CL}{F }</math>

Where:
:{|
| ''MD'' || is the maintenance dose rate [mg/h]
|-
| ''C<sub>p</sub>'' || = desired peak [[concentration]] of drug [mg/L]
|-
| ''CL'' || = [[Clearance (medicine)|clearance]] of drug in body [L/h]
|-
| ''F'' || = [[bioavailability]]
|}

For an intravenously administered drug, the bioavailability ''F'' will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

== See also ==
* [[Therapeutic index]]

==References==
{{reflist}}

{{Pharmacology}}

[[Category:Pharmacology]]

{{pharma-stub}}

Hele-Shaw flow - Revision history

en>Fgnievinski: /* See also */

en>Tony1 at 13:01, 22 July 2012