en>Riaddoc at 12:14, 1 October 2013

2013-10-01T12:14:41Z

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{{Infobox enzyme
| Name = Coenzyme F420-0:L-glutamate ligase
| EC_number = 6.3.2.31
| CAS_number =
| IUBMB_EC_number = 6/3/2/31
| GO_code =
| image =
| width =
| caption =
}}
'''Coenzyme F420-0:L-glutamate ligase''' ({{EC number|6.3.2.31}}, ''CofE-AF'', ''MJ0768'', ''CofE'') is an [[enzyme]] with system name ''L-glutamate:coenzyme F420-0 ligase (GDP-forming)''.<ref>{{cite journal | title = CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in ''Methanococcus jannaschii'' |author = Li, H., Graupner, M., Xu, H. and White, R.H. |journal = Biochemistry |year = 2003 |volume = 42 |pages = 9771–9778 |pmid = 12911320}}</ref><ref>{{cite journal | title = Structure of an amide bond forming F420:γ-glutamyl ligase from ''Archaeoglobus fulgidus'' — a member of a new family of non-ribosomal peptide synthases |author = Nocek, B., Evdokimova, E., Proudfoot, M., Kudritska, M., Grochowski, L.L., White, R.H., Savchenko, A., Yakunin, A.F., Edwards, A. and Joachimiak, A. |journal = J. Mol. Biol. |year = 2007 |volume = 372 |pages = 456–469 |pmid = 17669425}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: GTP + coenzyme F420-0 + L-[[glutamate]] <math>\rightleftharpoons</math> GDP + [[phosphate]] + coenzyme F420-1

This protein catalyses the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Coenzyme+F420-0:L-glutamate+ligase}}

[[Category:EC 6.3.2]]

Effect Model law - Revision history

en>Riaddoc at 12:14, 1 October 2013