en>Mogism: Cleanup/Typo fixing, typos fixed: are are → are using AWB

2013-08-16T17:15:31Z

Cleanup/Typo fixing, typos fixed: are are → are using AWB

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{{Infobox enzyme
| Name = Endo-alpha-N-acetylgalactosaminidase
| EC_number = 3.2.1.97
| CAS_number = 59793-96-3
| IUBMB_EC_number = 3/2/1/97
| GO_code =
| image =
| width =
| caption =
}}
'''Endo-alpha-N-acetylgalactosaminidase''' ({{EC number|3.2.1.97}}, ''endo-alpha-acetylgalactosaminidase'', ''endo-alpha-N-acetyl-D-galactosaminidase'', ''[[mucinaminylserine mucinaminidase]]'', ''D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine mucinaminohydrolase'', ''endo-alpha-GalNAc-ase'', ''D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase'') is an [[enzyme]] with system name ''glycopeptide-D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase''.<ref>{{cite journal | title = Characterization of two different endo-α-N-acetylgalactosaminidases from probiotic and pathogenic enterobacteria, Bifidobacterium longum and Clostridium perfringens |author = Ashida, H., Maki, R., Ozawa, H., Tani, Y., Kiyohara, M., Fujita, M., Imamura, A., Ishida, H., Kiso, M. and Yamamoto, K. |journal = Glycobiology |year = 2008 |volume = 18 |pages = 727–734 |pmid = 18559962}}</ref><ref>{{cite journal | title = Novel endo-α-N-acetylgalactosaminidases with broader substrate specificity |author = Koutsioulis, D., Landry, D. and Guthrie, E.P. |journal = Glycobiology |year = 2008 |volume = 18 |pages = 799–805 |pmid = 18635885}}</ref><ref>{{cite journal | title = Identification and molecular cloning of a novel glycoside hydrolase family of core 1 type O-glycan-specific endo-α-N-acetylgalactosaminidase from Bifidobacterium longum |author = Fujita, K., Oura, F., Nagamine, N., Katayama, T., Hiratake, J., Sakata, K., Kumagai, H. and Yamamoto, K. |journal = J. Biol. Chem. |year = 2005 |volume = 280 |pages = 37415–37422 |pmid = 16141207}}</ref><ref>{{cite journal | title = Crystallographic and mutational analyses of substrate recognition of endo-α-N-acetylgalactosaminidase from Bifidobacterium longum |author = Suzuki, R., Katayama, T., Kitaoka, M., Kumagai, H., Wakagi, T., Shoun, H., Ashida, H., Yamamoto, K. and Fushinobu, S. |journal = J. Biochem. |year = 2009 |volume = 146 |pages = 389–398 |pmid = 19502354}}</ref><ref>{{cite journal | title = Cloning, recombinant production, crystallization and preliminary X-ray diffraction analysis of a family 101 glycoside hydrolase from Streptococcus pneumoniae |author = Gregg, K.J. and Boraston, A.B. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |year = 2009 |volume = 65 |pages = 133–135 |pmid = 19194003}}</ref><ref>{{cite journal | title = Characterization of endo-α-N-acetylgalactosaminidase from Bacillus sp. and syntheses of neo-oligosaccharides using its transglycosylation activity |author = Ashida, H., Yamamoto, K., Murata, T., Usui, T. and Kumagai, H. |journal = Arch. Biochem. Biophys. |year = 2000 |volume = 373 |pages = 394–400 |pmid = 10620364}}</ref><ref>{{cite journal | title = Molecular cloning, expression, and characterization of a novel endo-α-N-acetylgalactosaminidase from Enterococcus faecalis |author = Goda, H.M., Ushigusa, K., Ito, H., Okino, N., Narimatsu, H. and Ito, M. |journal = Biochem. Biophys. Res. Commun. |year = 2008 |volume = 375 |pages = 441–446 |pmid = 18725192}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O <math>\rightleftharpoons</math> 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]

The enzyme catalyses the release of Gal-(1->3)-beta-GalNAc alpha-linked to [[serine]] or [[threonine]] residues of [[mucin]]-type [[glycoprotein]]s.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Endo-alpha-N-acetylgalactosaminidase}}

[[Category:EC 3.2.1]]

Anatree - Revision history

en>Mogism: Cleanup/Typo fixing, typos fixed: are are → are using AWB