View source for Senecionine N-oxygenase

{{enzyme
| Name = steroid 9-alpha-monooxygenase
| EC_number = 1.14.99.24
| CAS_number = 82869-33-8
| IUBMB_EC_number = 1/14/99/24
| GO_code = 0050292
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''steroid 9alpha-monooxygenase''' ({{EC number|1.14.99.24}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:pregna-4,9(11)-diene-3,20-dione + AH<sub>2</sub> + O<sub>2</sub> <math>\rightleftharpoons</math> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H<sub>2</sub>O

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[pregna-4,9(11)-diene-3,20-dione]], an [[electron acceptor]] AH<sub>2</sub>, and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[9,11alpha-epoxypregn-4-ene-3,20-dione]], the reduction product A, and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous.  The systematic name of this enzyme class is '''steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)'''. This enzyme is also called '''steroid 9alpha-hydroxylase'''.  It has 2 [[cofactor (biochemistry)|cofactors]]: [[Flavin mononucleotide|FMN]],  and [[Iron-sulfur]].  

==References==
{{reflist|1}}
* {{cite journal | doi = 10.1111/j.1432-1033.1982.tb06942.x | author = Strijewski A | date = 1982 | title = The steroid-9 alpha-hydroxylation system from Nocardia species | journal = Eur. J. Biochem.  | volume = 128 | pages = 125&ndash;35  | pmid = 7173200 | issue = 1 }}

{{1.14-enzyme-stub}}

[[Category:EC 1.14.99]]
[[Category:Flavin enzymes]]
[[Category:Iron-sulfur enzymes]]
[[Category:Enzymes of unknown structure]]