View source for Gibberellin-44 dioxygenase

{{enzyme
| Name = juglone 3-monooxygenase
| EC_number = 1.14.99.27
| CAS_number = 98865-54-4
| IUBMB_EC_number = 1/14/99/27
| GO_code = 0050012
| image = 
| width = 
| caption = 
}}
In [[enzymology]], '''juglone 3-monooxygenase''' ({{EC number|1.14.99.27}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:5-hydroxy-1,4-naphthoquinone + AH<sub>2</sub> + O<sub>2</sub> <math>\rightleftharpoons</math> 3,5-dihydroxy-1,4-naphthoquinone + A + H<sub>2</sub>O

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[5-hydroxy-1,4-naphthoquinone]], AH<sub>2</sub>, and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[3,5-dihydroxy-1,4-naphthoquinone]], A, and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O<sub>2</sub> as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is '''5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)'''. Other names in common use include '''juglone hydroxylase''', '''naphthoquinone hydroxylase''', and '''naphthoquinone-hydroxylase'''.

==References==
{{reflist|1}}
* {{cite journal | author = Rettenmaier H, Lingens F | year = 1985 | title = Purification and some properties of two isofunctional juglone hydroxylases from Pseudomonas putida J1 | journal = Biol. Chem. Hoppe-Seyler  | volume = 366 | pages = 637&ndash;46  | pmid = 4041238 | issue = 7 | doi = 10.1515/bchm3.1985.366.2.637 }}

[[Category:EC 1.14.99]]
[[Category:Enzymes of unknown structure]]


{{1.14-enzyme-stub}}