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{{enzyme
| Name = methylthioadenosine nucleosidase
| EC_number = 3.2.2.16
| CAS_number = 50812-28-7
| IUBMB_EC_number = 3/2/2/16
| GO_code = 0008930
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''methylthioadenosine nucleosidase''' ({{EC number|3.2.2.16}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:S-methyl-5'-thioadenosine + H<sub>2</sub>O <math>\rightleftharpoons</math> S-methyl-5-thio-D-ribose + adenine

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[S-methyl-5'-thioadenosine]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[S-methyl-5-thio-D-ribose]] and [[adenine]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those glycosylases that hydrolyse N-glycosyl compounds.  The systematic name of this enzyme class is '''S-methyl-5'-thioadenosine adeninehyrolase'''. Other names in common use include '''5'-methylthioadenosine nucleosidase''', '''MTA nucleosidase''', '''MeSAdo nucleosidase''', and '''methylthioadenosine methylthioribohydrolase'''.  This enzyme participates in [[urea cycle and metabolism of amino groups]] and [[methionine metabolism]].

==Structural studies==

As of late 2007, 6 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1NC1}}, {{PDB link|1NC3}}, {{PDB link|1Y6Q}}, {{PDB link|1Y6R}}, {{PDB link|1ZOS}}, and {{PDB link|2H8G}}.

==References==
{{reflist|1}}
* {{cite journal | author = Guranowski AB, Chiang PK, Cantoni GL | year = 1981 | title = 5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds | journal = Eur. J. Biochem.  | volume = 114 | pages = 293–9  | pmid = 6783408 | doi = 10.1111/j.1432-1033.1981.tb05148.x | issue = 2 }}

[[Category:EC 3.2.2]]
[[Category:Enzymes of known structure]]


{{hydrolase-stub}}