View source for Cytidylate kinase

{{enzyme
| Name = diacylglycerol cholinephosphotransferase
| EC_number = 2.7.8.2
| CAS_number = 9026-13-5
| IUBMB_EC_number = 2/7/8/2
| GO_code = 0004142
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''diacylglycerol cholinephosphotransferase''' ({{EC number|2.7.8.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:CDP-choline + 1,2-diacylglycerol <math>\rightleftharpoons</math> CMP + a phosphatidylcholine

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[CDP-choline]] and [[1,2-diacylglycerol]], whereas its two [[product (chemistry)|products]] are [[cytidine monophosphate|CMP]] and [[phosphatidylcholine]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring non-standard substituted phosphate groups.  The systematic name of this enzyme class is '''CDP choline:1,2-diacylglycerol cholinephosphotransferase'''. Other names in common use include '''phosphorylcholine-glyceride transferase''', '''alkylacylglycerol cholinephosphotransferase''', '''1-alkyl-2-acetylglycerol cholinephosphotransferase''', '''cholinephosphotransferase''', '''CPT''', '''alkylacylglycerol choline phosphotransferase''', '''diacylglycerol choline phosphotransferase''', '''1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase''', '''CDP-choline diglyceride phosphotransferase''', '''cytidine diphosphocholine glyceride transferase''', '''cytidine diphosphorylcholine diglyceride transferase''', '''phosphocholine diacylglyceroltransferase''', '''sn-1,2-diacylglycerol cholinephosphotransferase''', and '''1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase'''.  This enzyme participates in 3 [[metabolism|metabolic pathways]]: [[aminophosphonate metabolism]], [[glycerophospholipid metabolism]], and [[ether lipid metabolism]].  

==References==
{{reflist|1}}
* {{cite journal | author = Coleman R, Bell RM | date = 1977 | title = Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities | journal = J. Biol. Chem.  | volume = 252 | pages = 3050&ndash;6  | pmid = 192727 | issue = 9 }}
* {{cite journal | author = Lee TC, Blank ML, Fitzgerald V, Snyder F | date = 1982 | title = Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver | journal = Biochim. Biophys. Acta.  | volume = 713 | pages = 479&ndash;83  | pmid = 6295501 | issue = 2 }}
* {{cite journal | author = Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ | date = 1978 | title = Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate | journal = Lipids.  | volume = 13 | pages = 161&ndash;4  | pmid = 204847 | doi = 10.1007/BF02533260 | issue = 2 }}
* {{cite journal | author = Renooij W, Snyder F | date = 1981 | title = Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues | journal = Biochim. Biophys. Acta.  | volume = 663 | pages = 545&ndash;56  | pmid = 6260215 | issue = 2 }}

{{enzyme-stub}}

[[Category:EC 2.7.8]]
[[Category:Enzymes of unknown structure]]