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<div>{{Infobox enzyme<br />
| Name = D-alanine—(R)-lactate ligase<br />
| EC_number = 6.1.2.1<br />
| CAS_number = <br />
| IUBMB_EC_number = 6/1/2/1<br />
| GO_code = <br />
| image = <br />
| width = <br />
| caption =<br />
}}<br />
'''D-alanine—(R)-lactate ligase''' ({{EC number|6.1.2.1}}, ''VanA'', ''VanB'', ''VanD'') is an [[enzyme]] with system name ''D-alanine:(R)-lactate ligase (ADP-forming)''.<ref>{{cite journal | title = Molecular basis for vancomycin resistance in ''Enterococcus faecium'' BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA |author = Bugg, T.D., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. and Walsh, C.T. |journal = Biochemistry |year = 1991 |volume = 30 |pages = 10408–10415 |pmid = 1931965}}</ref><ref>{{cite journal | title = Purification and characterization of the VanB ligase associated with type B vancomycin resistance in ''Enterococcus faecalis'' V583 |author = Meziane-Cherif, D., Badet-Denisot, M.A., Evers, S., Courvalin, P. and Badet, B. |journal = FEBS Lett. |year = 1994 |volume = 354 |pages = 140–142 |pmid = 7957913}}</ref><ref>{{cite journal | title = VanD-type glycopeptide-resistant ''Enterococcus faecium'' BM4339 |author = Perichon, B., Reynolds, P. and Courvalin, P. |journal = Antimicrob. Agents Chemother. |year = 1997 |volume = 41 |pages = 2016–2018 |pmid = 9303405}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<br />
<br />
: D-[[alanine]] + (R)-[[Lactic acid|lactate]] + ATP <math>\rightleftharpoons</math> D-alanyl-(R)-lactate + ADP + [[phosphate]]<br />
<br />
The product of this enzyme can be incorporated into the [[peptidoglycan pentapeptide]] instead of the usual D-alanyl-D-alanine dipeptide.<br />
<br />
== References ==<br />
{{reflist}}<br />
<br />
== External links ==<br />
* {{MeshName|D-alanine---(R)-lactate+ligase}}<br />
<br />
{{DEFAULTSORT:D-alanine-(R)-lactate ligase}}<br />
[[Category:EC 6.1.2]]</div>
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