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'''C<sub>min</sub>''' is a term used in pharmacokinetics usually refers to the minimum plasma concentration that a drug achieves in tested area after the drug has been administrated and prior to the administration of a second dose. C<sub>min</sub> is the opposite of [[CMax|C<sub>max</sub>]], which is the maximum concentration that a drug achieves after dosing.'''C<sub>min</sub>''' has direct relationships with other minimum concentrations such as [[Minimum inhibitory concentration|MIC]] and is required to be higher than those concentrations to achieve the minimum efficacy.<br />
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In most cases Cmin is directly measurable. At steady state the minimum plasma concentration can also be calculated using the following equation:<ref>http://www.pharmpress.com/files/docs/clinical_pharmacokinetics_samplechapter.pdf</ref><br />
<center><math>C_{p min}= \frac{SFD k_a}{V_d(k_a-k)}\times\{\frac{e^{-k\tau}}{1-e^{-k\tau}}-\frac{e^{-k_a\tau}}{1-e^{-k_a\tau}}\}</math></center><br />
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Cmin is also a very important parameter in BA/BE studies, it is part of the pharmacokinetic information recommended for submission of IND.<ref>http://www.fda.gov/downloads/Drugs/.../Guidances/ucm070124.pdf</ref><br />
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==References==<br />
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[[Category:Pharmacokinetics]]<br />
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