https://en.formulasearchengine.com/w/api.php?action=feedcontributions&feedformat=atom&user=78.128.188.193formulasearchengine - User contributions [en]2026-08-12T03:39:43ZUser contributionsMediaWiki 1.47.0-wmf.7https://en.formulasearchengine.com/w/index.php?title=Benzoin_aldolase&diff=19659Benzoin aldolase2013-11-04T07:17:32Z<p>78.128.188.193: </p>
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<div>{{enzyme<br />
| Name = citrate (pro-3S)-lyase<br />
| EC_number = 4.1.3.6<br />
| CAS_number = 9012-83-3<br />
| IUBMB_EC_number = 4/1/3/6<br />
| GO_code = 0008815<br />
| image = <br />
| width = <br />
| caption = <br />
}}<br />
In [[enzymology]], a '''citrate (pro-3S)-lyase''' ({{EC number|4.1.3.6}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]<br />
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:citrate <math>\rightleftharpoons</math> acetate + oxaloacetate<br />
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Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[citrate]], and two [[product (chemistry)|products]], [[acetate]] and [[oxaloacetate]].<br />
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This enzyme belongs to the family of [[lyase]]s, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is '''citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate)'''. Other names in common use include '''citrase''', '''citratase''', '''citritase''', '''citridesmolase''', '''citrate aldolase''', '''citric aldolase''', '''citrate lyase''', '''citrate oxaloacetate-lyase''', and '''citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]'''. This enzyme participates in [[citrate cycle (tca cycle)]] and [[two-component system - general]]. <br />
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==Structural studies==<br />
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As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1U5H}}, {{PDB link|1U5V}}, {{PDB link|1Z6K}}, and {{PDB link|2HJ0}}.<br />
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==References==<br />
{{reflist|1}}<br />
* {{cite journal | author = DAGLEY S, DAWES EA | date = 1955 | title = Citridesmolase: its properties and mode of action | journal = Biochim. Biophys. Acta. | volume = 17 | pages = 177&ndash;84 | pmid = 13239657 | doi = 10.1016/0006-3002(55)90348-6 | issue = 2 }}<br />
* {{cite journal | author = Dimroth P, Loyal R, Eggerer H | date = 1977 | title = Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate | journal = Eur. J. Biochem. | volume = 80 | pages = 479&ndash;88 | pmid = 336371 | doi = 10.1111/j.1432-1033.1977.tb11903.x | issue = 2 }}<br />
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{{4.1-enzyme-stub}}<br />
<br />
[[Category:EC 4.1.3]]<br />
[[Category:Enzymes of known structure]]</div>78.128.188.193