T-coloring

2013-01-27T18:34:10Z

190.31.7.171:

{{Infobox enzyme
| Name = Hypoxia-inducible factor-asparagine dioxygenase
| EC_number = 1.14.11.30
| CAS_number =
| IUBMB_EC_number = 1/14/11/30
| GO_code =
| image =
| width =
| caption =
}}
'''Hypoxia-inducible factor-asparagine dioxygenase''' ({{EC number|1.14.11.30}}, ''HIF hydroxylase'') is an [[enzyme]] with system name ''hypoxia-inducible factor-L-asparagine, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)''.<ref>{{cite journal | title = FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity |author = Mahon, P.C., Hirota, K. and Semenza, G.L. |journal = Genes Dev. |year = 2001 |volume = 15 |pages = 2675–2686 |pmid = 11641274 | doi = 10.1101/gad.924501 | issue = 20 | pmc = 312814}}</ref><ref>{{cite journal | title = Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family |author = Hewitson, K.S., McNeill, L.A., Riordan, M.V., Tian, Y.M., Bullock, A.N., Welford, R.W., Elkins, J.M., Oldham, N.J., Bhattacharya, S., Gleadle, J.M., Ratcliffe, P.J., Pugh, C.W. and Schofield, C.J. |journal = J. Biol. Chem. |year = 2002 |volume = 277 |pages = 26351–26355 |pmid = 12042299 | doi = 10.1074/jbc.C200273200 | issue = 29}}</ref><ref>{{cite journal | title = Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway |author = Dann, C.E., 3rd, Bruick, R.K. and Deisenhofer, J. |journal = Proc. Natl. Acad. Sci. USA |year = 2002 |volume = 99 |pages = 15351–15356 |pmid = 12432100 | bibcode = 2002PNAS...9915351D | last2 = Bruick | last3 = Deisenhofer | doi = 10.1073/pnas.202614999 | issue = 24 | pmc = 137720}}</ref><ref>{{cite journal | title = Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch |author = Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J. and Whitelaw, M.L. |journal = Science |year = 2002 |volume = 295 |pages = 858–861 |pmid = 11823643 | bibcode = 2002Sci...295..858L | last2 = Peet | last3 = Whelan | last4 = Gorman | last5 = Whitelaw | doi = 10.1126/science.1068592 | issue = 5556}}</ref><ref>{{cite journal | title = Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases |author = Koivunen, P., Hirsila, M., Gunzler, V., Kivirikko, K.I. and Myllyharju, J. |journal = J. Biol. Chem. |year = 2004 |volume = 279 |pages = 9899–9904 |pmid = 14701857 | doi = 10.1074/jbc.M312254200 | issue = 11}}</ref><ref>{{cite journal | title = Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 α |author = Elkins, J.M., Hewitson, K.S., McNeill, L.A., Seibel, J.F., Schlemminger, I., Pugh, C.W., Ratcliffe, P.J. and Schofield, C.J. |journal = J. Biol. Chem. |year = 2003 |volume = 278 |pages = 1802–1806 |pmid = 12446723 | doi = 10.1074/jbc.C200644200 | issue = 3}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[hypoxia-inducible factor]]-L-[[asparagine]] + [[2-oxoglutarate]] + O<sub>2</sub> <math>\rightleftharpoons</math> hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + [[succinate]] + CO<sub>2</sub>

Hypoxia-inducible factor-asparagine dioxygenase contains [[iron]], and requires [[ascorbate]].

== References ==
{{reflist}}

== External links ==
*{{MeshName|Hypoxia-inducible+factor-asparagine+dioxygenase}}

[[Category:EC 1.14.11]]

formulasearchengine - User contributions [en]

T-coloring