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Order tracking (signal processing)
2013-09-22T02:07:13Z
<p>132.3.41.79: /* Computed order tracking */</p>
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<div>{{Infobox enzyme<br />
| Name = Sphingomyelin deacylase<br />
| EC_number = 3.5.1.109<br />
| CAS_number = <br />
| IUBMB_EC_number = 3/5/1/109<br />
| GO_code = <br />
| image = <br />
| width = <br />
| caption =<br />
}}<br />
'''Sphingomyelin deacylase''' ({{EC number|3.5.1.109}}, ''SM deacylase'', ''GcSM deacylase'', ''glucosylceramide sphingomyelin deacylase'', ''sphingomyelin glucosylceramide deacylase'', ''SM glucosylceramide GCer deacylase'', ''SM-GCer deacylase'', ''SMGCer deacylase'') is an [[enzyme]] with system name ''N-acyl-sphingosylphosphorylcholine amidohydrolase''.<ref>{{cite journal | title = High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis |author = Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. |journal = J. Invest. Dermatol. |date = 2000 |volume = 115 |pages = 406-413 |pmid = 10951276}}</ref><ref>{{cite journal | title = The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the <em>N</em>-acyl linkage of sphingomyelin and glucosylceramide |author = Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. |journal = Biochem. J. |date = 2000 |volume = 350 |pages = 747-756 |pmid = 10970788}}</ref><ref>{{cite journal | title = Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis |author = Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. |journal = Lab. Invest. |date = 2003 |volume = 83 |pages = 397-408 |pmid = 12649340}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<br />
<br />
: (1) an N-acyl-sphingosylphosphorylcholine + H<sub>2</sub>O <math>\rightleftharpoons</math> a [[fatty acid]] + [[sphingosylphosphorylcholine]];; <br />
: (2) a D-glucosyl-N-acylsphingosine + H<sub>2</sub>O <math>\rightleftharpoons</math> a fatty acid + D-glucosyl-sphingosine<br />
<br />
The enzyme is involved in the [[sphingolipid]] metabolism in the [[Epidermis (skin)|epidermis]].<br />
<br />
== References ==<br />
{{reflist}}<br />
<br />
== External links ==<br />
* {{MeshName|Sphingomyelin+deacylase}}<br />
<br />
[[Category:Hydrolases acting on nonpeptide C-N bonds]]<br />
[[Category:EC 3.5.1]]</div>
132.3.41.79