https://en.formulasearchengine.com/w/api.php?action=feedcontributions&feedformat=atom&user=129.67.56.124formulasearchengine - User contributions [en]2026-07-15T07:02:20ZUser contributionsMediaWiki 1.47.0-wmf.7https://en.formulasearchengine.com/w/index.php?title=Glycine%E2%80%94tRNA_ligase&diff=19801Glycine—tRNA ligase2014-01-27T12:12:52Z<p>129.67.56.124: </p>
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<div>{{enzyme<br />
| Name = leucine-tRNA ligase<br />
| EC_number = 6.1.1.4<br />
| CAS_number = 9031-15-6<br />
| IUBMB_EC_number = 6/1/1/4<br />
| GO_code = 0004823<br />
| image = <br />
| width = <br />
| caption = <br />
}}<br />
In [[enzymology]], a '''leucine-tRNA ligase''' ({{EC number|6.1.1.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]<br />
<br />
:ATP + L-leucine + tRNALeu <math>\rightleftharpoons</math> AMP + diphosphate + L-leucyl-tRNALeu<br />
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The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[L-leucine]], and [[tRNA(Leu)]], whereas its 3 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], and [[L-leucyl-tRNA(Leu)]].<br />
<br />
This enzyme belongs to the family of [[ligase]]s, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is '''L-leucine:tRNALeu ligase (AMP-forming)'''. Other names in common use include '''leucyl-tRNA synthetase''', '''leucyl-transfer ribonucleate synthetase''', '''leucyl-transfer RNA synthetase''', '''leucyl-transfer ribonucleic acid synthetase''', '''leucine-tRNA synthetase''', and '''leucine translase'''. This enzyme participates in [[valine, leucine and isoleucine biosynthesis]] and [[aminoacyl-trna biosynthesis]].<br />
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==Structural studies==<br />
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As of late 2007, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1WKB}}, {{PDB link|1WZ2}}, {{PDB link|2AJG}}, {{PDB link|2AJH}}, and {{PDB link|2AJI}}.<br />
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==See also==<br />
*[[Leucyl-tRNA synthetase]]<br />
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==References==<br />
{{reflist|1}}<br />
* {{cite journal | author = ALLEN EH, GLASSMAN E, SCHWEET RS | year = 1960 | title = Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes | journal = J. Biol. Chem. | volume = 235 | pages = 1061&ndash;7 | pmid = 13792726 }}<br />
* {{cite journal | author = Berg P, Bergmann FH, Ofengand EJ and Dieckmann M | year = 1961 | title = The enzymic synthesis of amino acyl derivatives of ribonucleic acid I. The mechanism of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid formation | journal = J. Biol. Chem. | volume = 236 | pages = 1726&ndash;1734 }}<br />
* {{cite journal | author = Bergmann FH, Berg P and Dieckmann M | year = 1961 | title = The enzymic synthesis of amino acyl derivatives of ribonucleic acid II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli | journal = J. Biol. Chem. | volume = 236 | pages = 1735&ndash;1740 }}<br />
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{{Ligases}}<br />
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{{DEFAULTSORT:Leucine-tRNA ligase}}<br />
[[Category:EC 6.1.1]]<br />
[[Category:Enzymes of known structure]]<br />
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{{ligase-stub}}</div>129.67.56.124