Superoxide reductase

2013-07-03T18:00:37Z

128.192.34.140:

{{enzyme
| Name = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
| EC_number = 1.13.11.25
| CAS_number = 37256-63-6
| IUBMB_EC_number = 1/13/11/25
| GO_code = 0047071
| image =
| width =
| caption =
}}
In [[enzymology]], a '''3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase''' ({{EC number|1.13.11.25}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <math>\rightleftharpoons</math> 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione]] and [[oxygen|O2]], whereas its [[product (chemistry)|product]] is [[3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is '''3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)'''. Other names in common use include '''steroid 4,5-dioxygenase''', and '''3-alkylcatechol 2,3-dioxygenase'''. It employs one [[cofactor (biochemistry)|cofactor]], [[iron]].

==References==
{{reflist|1}}
* {{cite journal | author = Gibson DT, Wang KC, Sih CJ, Whitlock H Jr | date = 1966 | title = Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms | journal = J. Biol. Chem. | volume = 241 | pages = 551–9 | pmid = 5908121 | issue = 3 }}

[[Category:EC 1.13.11]]
[[Category:Iron enzymes]]
[[Category:Enzymes of unknown structure]]

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Superoxide reductase