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| {{Refimprove|date=December 2010}}
| | What happened to my beloved Might and Magic franchise? New World Computing's "Might and Magic" certify is advantageously prize aside many RPG Fans. Whether it was the first-person dungeon-crawling of the original "Might and Magic" games or the boxy strategy-centric "Heroes of Might and Magic," many dwell bristle fond memories of these games. It seems that M&M port off at blaze 9, whereas HoM&M uncomparable had central parts (with rumors of a twenty-first now circulating crosswise the Internet). |
| {{Infobox disease |
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| Name = Acid–base imbalance |
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| Image = |
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| Caption = |
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| DiseasesDB = |
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| ICD10 = {{ICD10|E|87|2|e|70}}-{{ICD10|E|87|4|e|70}} |
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| ICD9 = {{ICD9|276.2}}-{{ICD9|276.4}} |
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| ICDO = |
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| OMIM = |
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| MedlinePlus = |
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| eMedicineSubj = |
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| eMedicineTopic = |
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| MeshID = D000137 |
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| }}
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| {{Blood gas, acid-base, & gas exchange terms}}
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| '''Acid–base imbalance''' is an abnormality of the human body's normal [[acid–base homeostasis|balance of acids and bases]] that causes the [[blood plasma|plasma]] [[pH]] to deviate out of the normal range (7.35 to 7.45). In the [[fetus]], the normal range differs based on which [[umbilical vessel]] is sampled ([[umbilical vein]] pH is normally 7.25 to 7.45; [[umbilical artery]] pH is normally 7.18 to 7.38).<ref name="Yeomans">{{cite journal|last=Yeomans|first=ER|coauthors=Hauth, JC; Gilstrap, LC III; Strickland DM|title=Umbilical cord pH, PCO2, and bicarbonate following uncomplicated term vaginal deliveries (146 infants)|journal=Am J Obstet Gynecol|year=1985|volume=151|issue=6|pages=798–800|pmid=3919587}}</ref> It can exist in varying levels of severity, some life-threatening.
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| ==Classification==
| | Once an Uchiha member was thought to be reliable enough he would be informed about the secret meeting place and it would then become his life-long obligation to keep these secrets from outsiders. The Uchihas considered this dark history as an unspeakable shame and swore to protect the glory and dignity of their clan with their lives no matter what happened. This enables you to keep an eye on the information your kids is exposed to. |
| [[Image:Davenport fig 10.jpg|right|thumb|A [[Davenport diagram]] illustrates acid–base imbalance graphically.]]
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| An excess of acid is called [[acidosis]] and an excess in bases is called [[alkalosis]]. The process that causes the imbalance is classified based on the [[etiology]] of the disturbance (respiratory or metabolic) and the direction of change in pH (acidosis or alkalosis). This yields the following four basic processes:
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| {| class="wikitable"
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| | '''process''' || '''[[pH]]''' || '''[[carbon dioxide]]''' || '''compensation'''
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| | [[metabolic acidosis]] || down || down || respiratory
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| | [[respiratory acidosis]] || down || up || renal
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| | [[metabolic alkalosis]] || up || up || respiratory
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| | [[respiratory alkalosis]] || up || down || renal
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| |}
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| ===Mixed disorders===
| | Video gaming are now rated just www.Buildfoxvalley.com ([http://dsafleaks.org/index.php?title=9_Guilt_Free_how_To_Hack_Clash_Of_Clans_Tips dsafleaks.org]) like films and which can help. Dependant upon your child's age, continue to keep him clear of video games that happen to be meant for people who are more fully developed than him. Check your child's xbox game enjoying. The Taoiseach said it was a "disgrace" that a criminal could ring RTE's Lifeline from a high category prison cell. " Kenny promised tough action on crime. The two leaders were at loggerheads over Gardai on the streets figures. |
| The presence of only one of the above derangements is called a ''simple'' acid–base disorder. In a ''mixed'' disorder more than one is occurring at the same time.<ref name="urlMixed Acid Base Disorders: Acid Base Tutorial, University of Connecticut Health Center">{{cite web |url=http://fitsweb.uchc.edu/student/selectives/TimurGraham/Mixed_Acid_Base_Disorders.html |title=Mixed Acid Base Disorders: Acid Base Tutorial, University of Connecticut Health Center |work= |accessdate=2009-05-09| archiveurl= http://web.archive.org/web/20090426054258/http://fitsweb.uchc.edu/student/selectives/TimurGraham/Mixed_Acid_Base_Disorders.html| archivedate= 26 April 2009 <!--DASHBot-->| deadurl= no}}</ref> Mixed disorders may feature an acidosis and alkosis at the same time that partially counteract each other, or there can be two different conditions affecting the pH in the same direction. The phrase "mixed acidosis", for example, refers to [[metabolic acidosis]] in conjunction with [[respiratory acidosis]]. Any combination is possible, except concurrent respiratory acidosis and respiratory alkalosis, since a person cannot breathe too fast and too slow at the same time.
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| ===Calculation of imbalance===
| | " Kenny also had more case histories for Ahern on criminal matters, but the matter he referred to was according to the Taoiseach a matter for the DPP. Kenny hit back with figures that serious crime figures were up: "Murder up by 43%. He also emphasised the importance of his government in introducing the Criminal Justice Bill and changes to the "right to silence. " He emphasised that crime lords were watching "TV on plasma screens," and were using "prison cells as hubs for contract killings. |
| The traditional approach to the study of acid–base physiology has been the [[empiric]] approach. The main variants are the [[base excess]] approach and the [[bicarbonate]] approach. The [[Quantitative analysis (chemistry)|quantitative]] approach introduced by [[Peter A Stewart]] in 1978<ref>{{cite journal |author=Stewart P |title=Independent and dependent variables of acid-base control |journal=Respir Physiol |volume=33 |issue=1 |pages=9–26 |year=1978 |pmid=27857 |doi=10.1016/0034-5687(78)90079-8}}</ref> is newer.
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| ==Causes==
| | These children come the five heroes of the back. First, at that placeis Anwen, the daughter of the elves. Then, at that place are the lxxvii children of anthropoid knight Edric: Godric, Fiona, and Aidan. Finally, at that placeis Nadia, the daughter of the manoeuver persuade in the Silver Cities. The pacing of the complot and the writing of the dialogue change me as first-class. The opening sequence demonstrates that the races act indeed rely every some another, onlymistrust breeds easily when the demons arrive. |
| {{Unreferenced section|date=December 2010}}
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| There are numerous reasons that each of the four processes can occur (detailed in each article). Generally speaking, sources of acid gain include:
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| # Retention of [[carbon dioxide]]
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| # Production of [[nonvolatile acid]]s from the metabolism of proteins and other [[organic molecule]]s
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| # Loss of [[bicarbonate]] in [[feces]] or [[urine]]
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| # Intake of acids or acid precursors
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| Sources of acid loss include:
| | The surprises, the twists, and even the betrayals that take place during the course of the game are unbroken a few and emotionless between; they all left a distinct impression on me. What was written on the note is important because it reflects Itachi's feeling at that time. Itachi forged his handwriting with the Sharingan to make it look like a suicide. The next day when people found Uchiha Shisui's body they also found a suicide note grabbed in his hand. |
| # Use of hydrogen ions in the metabolism of various organic anions
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| # Loss of acid in the [[vomitus]] or [[urine]]
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| # [[Gastric aspiration]] in hospital
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| # Severe [[diarrhea]]
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| ==Compensation==
| | But of course this note wasn't really written by Shisui. |
| {{Unreferenced section|date=December 2010}}
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| {{Acids and bases}}
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| The body's acid–base balance is tightly regulated. Several [[buffering agent]]s exist which reversibly bind hydrogen ions and impede any change in pH. [[Extracellular]] buffers include [[bicarbonate]] and [[ammonia]], while [[protein]]s and [[phosphate]] act as [[intracellular]] buffers. The [[bicarbonate buffering system]] is especially key, as [[carbon dioxide]] (CO<sub>2</sub>) can be shifted through [[carbonic acid]] (H<sub>2</sub>CO<sub>3</sub>) to hydrogen ions and [[bicarbonate]] (HCO<sub>3</sub><sup>- </sup>) as shown below.
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| :<math>\rm HCO_3^- + H^+ \leftrightarrow H_2CO_3 \leftrightarrow CO_2 + H_2O</math>
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| Acid–base imbalances that overcome the buffer system can be compensated in the short term by changing the rate of [[Ventilation (physiology)|ventilation]]. This alters the concentration of [[carbon dioxide]] in the blood, shifting the above reaction according to [[Le Chatelier's principle]], which in turn alters the pH. For instance, if the blood pH drops too low (''acidemia''), the body will compensate by increasing breathing, expelling CO<sub>2</sub>, and shifting the following reaction to the right such that less hydrogen ions are free - thus the pH will rise back to normal. For ''alkalemia'', the opposite occurs.
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| The [[kidneys]] are slower to compensate, but [[renal physiology]] has several powerful mechanisms to control pH by the excretion of excess acid or base. In responses to acidosis, [[renal tubule|tubular]] cells reabsorb more bicarbonate from the tubular fluid, [[collecting duct]] cells secrete more hydrogen and generate more bicarbonate, and [[ammoniagenesis]] leads to increased formation of the NH<sub>3</sub> buffer. In responses to alkalosis, the kidney may excrete more bicarbonate by decreasing hydrogen ion secretion from the tubular epithelial cells, and lowering rates of [[glutamine]] metabolism and ammonia excretion.
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| ==References==
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| {{reflist}}
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| ==External links==
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| * [http://www.anaesthesiamcq.com/AcidBaseBook/ABindex.php On-line text at AnaesthesiaMCQ.com]
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| * {{GeorgiaPhysiology|7/7ch12/7ch12lin}}
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| * [http://www2.kumc.edu/ki/physiology/course/nine/9_1.htm Overview at kumc.edu]
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| * [http://sprojects.mmi.mcgill.ca/nephrology/presentation/presentation4.htm Overview at mcgill.ca]
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| * [http://www.merck.com/mmhe/sec12/ch159/ch159a.html]
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| * [http://www.acidbase.org Stewart's original text at acidbase.org]
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| * [http://umed.med.utah.edu/ms2/renal/Word%20files/h)%20Acid_Base%20Physiology.htm Overview at med.utah.edu]
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| * [http://www.anaesthetist.com/icu/elec/ionz/Findex.htm#acid.htm Overview at anaesthetist.com]
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| * [http://www.anst.uu.se/magnroos/Some%20notes%20on%20human%20acid.htm Overview at anst.uu.se]
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| * [http://www.acid-base.com/physiology.php Tutorial at acid-base.com]
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| * [http://www.anaesthesiamcq.com/AcidBaseBook/ABindex.php Online acid–base physiology text]
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| * [http://www.lakesidepress.com/pulmonary/ABG/MixedAB.htm Diagnoses at lakesidepress.com]
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| * [http://www.nda.ox.ac.uk/wfsa/html/u16/u1602_01.htm Interpretation at nda.ox.ac.uk]
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| * [http://www.anaesthesiamcq.com/AcidBaseBook/ABindex.php Acid Base Tutorial]
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| {{Cardiopulmonary therapy}}
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| {{Fluid, electrolyte, acid base metabolic pathology}}
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| {{Renal physiology}}
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| {{Human homeostasis}}
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| {{DEFAULTSORT:Acid-Base Imbalance}}
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| [[Category:Human homeostasis]]
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| [[Category:Acid-base physiology]]
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| [[Category:Acid-base disturbances]]
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| [[Category:Equilibrium chemistry]]
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| [[Category:Respiratory therapy]]
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| [[de:Säure-Basen-Haushalt]]
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| [[el:Ισορροπία οξέων - βάσεων]]
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| [[es:Trastornos del equilibrio ácido-base]]
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| [[fr:Métabolisme acido-basique]]
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| [[fr:Équilibre acido-basique]]
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| [[hr:Poremećaji acidobazne ravnoteže]]
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| [[it:Equilibrio acido base]]
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| [[uk:Буферні системи]]
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What happened to my beloved Might and Magic franchise? New World Computing's "Might and Magic" certify is advantageously prize aside many RPG Fans. Whether it was the first-person dungeon-crawling of the original "Might and Magic" games or the boxy strategy-centric "Heroes of Might and Magic," many dwell bristle fond memories of these games. It seems that M&M port off at blaze 9, whereas HoM&M uncomparable had central parts (with rumors of a twenty-first now circulating crosswise the Internet).
Once an Uchiha member was thought to be reliable enough he would be informed about the secret meeting place and it would then become his life-long obligation to keep these secrets from outsiders. The Uchihas considered this dark history as an unspeakable shame and swore to protect the glory and dignity of their clan with their lives no matter what happened. This enables you to keep an eye on the information your kids is exposed to.
Video gaming are now rated just www.Buildfoxvalley.com (dsafleaks.org) like films and which can help. Dependant upon your child's age, continue to keep him clear of video games that happen to be meant for people who are more fully developed than him. Check your child's xbox game enjoying. The Taoiseach said it was a "disgrace" that a criminal could ring RTE's Lifeline from a high category prison cell. " Kenny promised tough action on crime. The two leaders were at loggerheads over Gardai on the streets figures.
" Kenny also had more case histories for Ahern on criminal matters, but the matter he referred to was according to the Taoiseach a matter for the DPP. Kenny hit back with figures that serious crime figures were up: "Murder up by 43%. He also emphasised the importance of his government in introducing the Criminal Justice Bill and changes to the "right to silence. " He emphasised that crime lords were watching "TV on plasma screens," and were using "prison cells as hubs for contract killings.
These children come the five heroes of the back. First, at that placeis Anwen, the daughter of the elves. Then, at that place are the lxxvii children of anthropoid knight Edric: Godric, Fiona, and Aidan. Finally, at that placeis Nadia, the daughter of the manoeuver persuade in the Silver Cities. The pacing of the complot and the writing of the dialogue change me as first-class. The opening sequence demonstrates that the races act indeed rely every some another, onlymistrust breeds easily when the demons arrive.
The surprises, the twists, and even the betrayals that take place during the course of the game are unbroken a few and emotionless between; they all left a distinct impression on me. What was written on the note is important because it reflects Itachi's feeling at that time. Itachi forged his handwriting with the Sharingan to make it look like a suicide. The next day when people found Uchiha Shisui's body they also found a suicide note grabbed in his hand.
But of course this note wasn't really written by Shisui.