2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: Difference between revisions

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{{enzyme
| Name = 6-phosphofructo-2-kinase
| EC_number = 2.7.1.105
| CAS_number = 78689-77-7
| IUBMB_EC_number = 2/7/1/105
| GO_code = 0003873
| image =
| width =
| caption =
}}
{{Infobox protein family
| Symbol = 6PF2K
| Name = 6PF2K
| image = PDB 1k6m EBI.jpg
| width =
| caption = crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
| Pfam = PF01591
| Pfam_clan = CL0023
| InterPro = IPR013079
| SMART =
| PROSITE = PDOC00158
| MEROPS =
| SCOP = 1bif
| TCDB =
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}
In [[enzymology]], a '''6-phosphofructo-2-kinase''' ({{EC number|2.7.1.105}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:ATP + beta-D-fructose 6-phosphate <math>\rightleftharpoons</math> ADP + beta-D-fructose 2,6-bisphosphate
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[beta-D-fructose 6-phosphate]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[beta-D-fructose 2,6-bisphosphate]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptorThe systematic name of this enzyme class is '''ATP:beta-D-fructose-6-phosphate 2-phosphotransferase'''. Other names in common use include '''phosphofructokinase 2''', '''6-phosphofructose 2-kinase''', '''6-phosphofructo-2-kinase (phosphorylating)''', '''fructose 6-phosphate 2-kinase''', and '''ATP:D-fructose-6-phosphate 2-phosphotransferase'''.  This enzyme participates in [[Fructose metabolism|fructose]] and [[Mannose metabolism|mannose metabolism]]. The enzyme is important in the [[regulation]] of [[liver|hepatic]] [[carbohydrate]] [[metabolism#Regulation_and_control|metabolism]] and is found in greatest quantities in the liver, [[kidney]] and [[heart]]. In mammals, several [[genes]] often encode different isoforms, each of which differs in its [[tissue (biology)|tissue]] distribution and [[enzyme|enzymatic]] activity.<ref name="pmid9652401">{{cite journal | author = Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S | title = Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2) | journal = Eur. J. Biochem. | volume = 254 | issue = 1 | pages = 103–10 |date=May 1998 | pmid = 9652401 | doi = 10.1046/j.1432-1327.1998.2540103.x| url = }}</ref> The [[family (biology)|family]] described here bears a resemblance to the ATP-driven phospho-fructokinases, however, they share little [[sequence (biology)|sequence]] similarity, although a few [[residue (chemistry)|residues]] seem key to their interaction with [[fructose 6-phosphate]].<ref name="pmid9753654">{{cite journal | author = Wang X, Deng Z, Kemp RG | title = An essential methionine residue involved in substrate binding by phosphofructokinases | journal = Biochem. Biophys. Res. Commun. | volume = 250 | issue = 2 | pages = 466–8 |date=September 1998 | pmid = 9753654 | doi = 10.1006/bbrc.1998.9311 | url = }}</ref>
 
==Structural studies==
 
As of late 2007, 8 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1BIF}}, {{PDB link|1K6M}}, {{PDB link|2AXN}}, {{PDB link|2BIF}}, {{PDB link|2DWO}}, {{PDB link|2DWP}}, {{PDB link|2I1V}}, and {{PDB link|3BIF}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Van Schaftingen E, Hers HG | year = 1981 | title = Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP | journal = Biochem. Biophys. Res. Commun. | volume = 101 | pages = 1078&ndash;84  | pmid = 6458291 | doi = 10.1016/0006-291X(81)91859-3 | issue = 3 }}
 
{{InterPro content|IPR013079}}
 
[[Category:Protein domains]]
[[Category:EC 2.7.1]]
[[Category:Enzymes of known structure]]
 
 
{{enzyme-stub}}

Revision as of 20:29, 7 January 2014

Template:Enzyme Template:Infobox protein family In enzymology, a 6-phosphofructo-2-kinase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + beta-D-fructose 6-phosphate ADP + beta-D-fructose 2,6-bisphosphate

Thus, the two substrates of this enzyme are ATP and beta-D-fructose 6-phosphate, whereas its two products are ADP and beta-D-fructose 2,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:beta-D-fructose-6-phosphate 2-phosphotransferase. Other names in common use include phosphofructokinase 2, 6-phosphofructose 2-kinase, 6-phosphofructo-2-kinase (phosphorylating), fructose 6-phosphate 2-kinase, and ATP:D-fructose-6-phosphate 2-phosphotransferase. This enzyme participates in fructose and mannose metabolism. The enzyme is important in the regulation of hepatic carbohydrate metabolism and is found in greatest quantities in the liver, kidney and heart. In mammals, several genes often encode different isoforms, each of which differs in its tissue distribution and enzymatic activity.[1] The family described here bears a resemblance to the ATP-driven phospho-fructokinases, however, they share little sequence similarity, although a few residues seem key to their interaction with fructose 6-phosphate.[2]

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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Template:InterPro content


Template:Enzyme-stub

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