Common-mode signal: Difference between revisions
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{{PBB|geneid=138050}} | |||
{{enzyme | |||
| Name = heparan-alpha-glucosaminide ''N''-acetyltransferase | |||
| EC_number = 2.3.1.78 | |||
| CAS_number = 79955-83-2 | |||
| IUBMB_EC_number = 2/3/1/78 | |||
| GO_code = 0015019 | |||
| image = | |||
| width = | |||
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}} | |||
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'''Heparan-α-glucosaminide ''N''-acetyltransferase''' (also called "acetyl-CoA:heparan-α-D-glucosaminide ''N''-acetyltransferase" and "acetyl-CoA:alpha-glucosaminide ''N''-acetyltransferase") is an [[enzyme]] that in humans is encoded by the ''HGSNAT'' [[gene]].<ref name="pmid17033958">{{cite journal | author = Hrebicek M, Mrazova L, Seyrantepe V, Durand S, Roslin NM, Noskova L, Hartmannova H, Ivanek R, Cizkova A, Poupetova H, Sikora J, Urinovska J, Stranecky V, Zeman J, Lepage P, Roquis D, Verner A, Ausseil J, Beesley CE, Maire I, Poorthuis BJ, van de Kamp J, van Diggelen OP, Wevers RA, Hudson TJ, Fujiwara TM, Majewski J, Morgan K, Kmoch S, Pshezhetsky AV | title = Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome) | journal = Am J Hum Genet | volume = 79 | issue = 5 | pages = 807–19 |date=Oct 2006 | pmid = 17033958 | pmc = 1698556 | doi = 10.1086/508294 }}</ref><ref name="pmid16960811">{{cite journal | author = Fan X, Zhang H, Zhang S, Bagshaw RD, Tropak MB, Callahan JW, Mahuran DJ | title = Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C) | journal = Am J Hum Genet | volume = 79 | issue = 4 | pages = 738–44 |date=Sep 2006 | pmid = 16960811 | pmc = 1592569 | doi = 10.1086/508068 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HGSNAT heparan-alpha-glucosaminide N-acetyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=138050| accessdate = }}</ref> | |||
In [[enzymology]], this enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than [[aminoacyl]] groups. It is [[catalysis|catalysed]] in the [[chemical reaction]]: | |||
:[[acetyl-CoA]] + [[heparan sulfate α-D-glucosaminide]] <math>\rightleftharpoons</math> [[Coenzyme A|CoA]] + [[heparan sulfate N-acetyl-α-D-glucosaminide]] | |||
This enzyme participates in [[glycosaminoglycan]] degradation and [[glycan]] structures degradation. [[Mutation]]s in the gene encoding this enzyme cause [[mucopolysaccharidosis]] IIIC.<ref name="pmid16960811"/> | |||
==References== | |||
{{reflist}} | |||
==Further reading== | |||
{{refbegin | 2}} | |||
{{PBB_Further_reading | |||
| citations = | |||
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | |||
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | |||
*{{cite journal | author=Ausseil J, Loredo-Osti JC, Verner A, ''et al.'' |title=Localisation of a gene for mucopolysaccharidosis IIIC to the pericentromeric region of chromosome 8. |journal=J. Med. Genet. |volume=41 |issue= 12 |pages= 941–5 |year= 2005 |pmid= 15591281 |doi= 10.1136/jmg.2004.021501 | pmc=1735628 }} | |||
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }} | |||
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} | |||
*{{cite journal | author=Nusbaum C, Mikkelsen TS, Zody MC, ''et al.'' |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }} | |||
*{{cite journal | author=Fedele AO, Filocamo M, Di Rocco M, ''et al.'' |title=Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome). Mutation in brief #959. Online. |journal=Hum. Mutat. |volume=28 |issue= 5 |pages= 523 |year= 2007 |pmid= 17397050 |doi= 10.1002/humu.9488 }} | |||
* {{cite journal | author = Klein U, Kresse H, von Figura K | date = 1978 | title = Sanfilippo syndrome type C: deficiency of acetyl-CoA:alpha-glucosaminide N-acetyltransferase in skin fibroblasts | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 75 | pages = 5185–9 | pmid = 33384 | doi = 10.1073/pnas.75.10.5185 | issue = 10 | pmc = 336290 }} | |||
* {{cite journal | author = Pohlmann R, Klein U, Fromme HG, von Figura K | date = 1981 | title = Localisation of acetyl-CoA: alpha-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver | journal = Hoppe. Seylers. Z. Physiol. Chem. | volume = 362 | pages = 1199–207 | pmid = 7346380 | issue = 9 | doi = 10.1515/bchm2.1981.362.2.1199 }} | |||
}} | |||
{{refend}} | |||
{{gene-8-stub}} | |||
{{transferase-stub}} | |||
{{Acyltransferases}} | |||
{{Glycosaminoglycan catabolism}} | |||
[[Category:EC 2.3.1]] | |||
[[Category:Enzymes of unknown structure]] | |||
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Revision as of 20:36, 17 January 2014
Template:PBB Template:Enzyme Template:PBB Summary Heparan-α-glucosaminide N-acetyltransferase (also called "acetyl-CoA:heparan-α-D-glucosaminide N-acetyltransferase" and "acetyl-CoA:alpha-glucosaminide N-acetyltransferase") is an enzyme that in humans is encoded by the HGSNAT gene.[1][2][3]
In enzymology, this enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. It is catalysed in the chemical reaction:
This enzyme participates in glycosaminoglycan degradation and glycan structures degradation. Mutations in the gene encoding this enzyme cause mucopolysaccharidosis IIIC.[2]
References
43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.
Further reading
Template:Refbegin Template:PBB Further reading Template:Refend
Template:Gene-8-stub Template:Transferase-stub Template:Acyltransferases Template:Glycosaminoglycan catabolism
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A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running
The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more
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In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang
Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules
Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.
A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running
The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more
There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang - ↑ Template:Cite web