Retardation factor

The Certain Safety Factor is the ratio of the lethal dose to 1% of population to the effective dose to 99% of the population (LD1/ED99). This is a better safety index than the LD₅₀ for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may be necessary to produce a response in one person but can, at the same dose, be lethal in another.

$\text{Certain safety factor}=\frac{{\mathrm{L}\mathrm{D}}_1}{{\mathrm{E}\mathrm{D}}_{99}}$

See also

• Therapeutic index
• Effective dose
• IC₅₀
• Template:LD50
• EC₅₀
• Toxicology

References

http://www.courses.vcu.edu/ptxed/m2/faqs_damaj.htm

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