Amenable Banach algebra: Difference between revisions
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{{enzyme | |||
| Name = phosphoribosylaminoimidazole carboxylase | |||
| EC_number = 4.1.1.21 | |||
| CAS_number = 9032-04-6 | |||
| IUBMB_EC_number = 4/1/1/21 | |||
| GO_code = 0004638 | |||
| image = | |||
| width = | |||
| caption = | |||
}} | |||
{{protein | |||
|Name=phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | |||
|caption= | |||
|image= | |||
|width= | |||
|HGNCid=8587 | |||
|Symbol=PAICS | |||
|AltSymbols=PAIS | |||
|EntrezGene=10606 | |||
|OMIM=172439 | |||
|RefSeq=NM_006452 | |||
|UniProt=P22234 | |||
|PDB= | |||
|ECnumber=4.1.1.21 | |||
|Chromosome=4 | |||
|Arm=p | |||
|Band=ter | |||
|LocusSupplementaryData=-q21 | |||
}} | |||
'''Phosphoribosylaminoimidazole carboxylase''' (or '''AIR carboxylase''') is an [[enzyme]] involved in [[nucleotide]] [[biosynthesis]] and in particular in [[purine biosynthesis]]. It catalyzes the conversion of [[5'-phosphoribosyl-5-aminoimidazole]] ("AIR") into [[5'-Phosphoribosyl-4-carboxy-5-aminoimidazole|5'-phosphoribosyl-4-carboxy-5-aminoimidazole]] ("CAIR") as described in the reaction: | |||
:5-aminoimidazole ribonucleotide + CO<sub>2</sub> <math>\rightleftharpoons</math> 5'-phosphoribosyl-4-carboxy-5-aminoimidazole + 2 H<sup>+</sup> | |||
==In plants and fungi== | |||
Phosphoribosylaminoimidazole carboxylase is a [[fusion protein]] in [[plant]]s and [[fungi]], but consists of two non-interacting proteins in bacteria, PurK and PurE. | |||
The crystal structure of PurE indicates a unique quaternary structure that confirms the octameric nature of the enzyme.<ref name="PUB00016906">{{cite journal |doi=10.1016/S0969-2126(00)80029-5 |author=Ealick SE, Stubbe J, Kappock TJ, Mathews II |title=Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway |journal=Structure |volume=7 |issue=11 |pages=1395–1406 |year=1999 |pmid=10574791}}</ref> | |||
==In ''Escherichia coli''== | |||
In the [[bacteria|bacterium]] ''[[Escherichia coli]]'' the reaction is catalyzed in two steps carried out by two separate enzymes, PurK and PurE. | |||
PurK, [[N5-carboxyaminoimidazole ribonucleotide synthetase|''N''5-carboxyaminoimidazole ribonucleotide synthetase]], catalyzes the conversion of 5-aminoimidazole ribonucleotide ("AIR"), [[Adenosine triphosphate|ATP]], and [[bicarbonate]] to ''N''5-carboxyaminoimidazole ribonucleotide ("N5-CAIR"), [[Adenosine diphosphate|ADP]], and [[Pi]]. | |||
PurE, [[N5-carboxyaminoimidazole ribonucleotide mutase|''N''5-carboxyaminoimidazole ribonucleotide mutase]], converts N5-CAIR to CAIR, the sixth step of ''de novo'' purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. Some members of this family contain two copies of this domain.<ref name="PUB00016905">{{cite journal |author=Meyer E, Stubbe J, Kappock TJ, Osuji C |title=Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by ''Escherichia coli'' PurE, an N5-CAIR mutase |journal=Biochemistry |volume=38 |issue=10 |pages=3012–3018 |year=1999 |pmid=10074353 |doi=10.1021/bi9827159}}</ref> | |||
==References== | |||
{{reflist}} | |||
==External links== | |||
* {{MeshName|phosphoribosylaminoimidazole+carboxylase}} | |||
*[http://bioch.szote.u-szeged.hu/astrojan/protein/pictures/paics2.jpg PAICS photo] | |||
{{biochem-stub}} | |||
{{Carbon-carbon lyases}} | |||
{{Nucleotide metabolism enzymes}} | |||
{{InterPro content|IPR000031}} | |||
Revision as of 22:01, 27 September 2012
Template:Enzyme Template:Protein
Phosphoribosylaminoimidazole carboxylase (or AIR carboxylase) is an enzyme involved in nucleotide biosynthesis and in particular in purine biosynthesis. It catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole ("AIR") into 5'-phosphoribosyl-4-carboxy-5-aminoimidazole ("CAIR") as described in the reaction:
In plants and fungi
Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE.
The crystal structure of PurE indicates a unique quaternary structure that confirms the octameric nature of the enzyme.[1]
In Escherichia coli
In the bacterium Escherichia coli the reaction is catalyzed in two steps carried out by two separate enzymes, PurK and PurE.
PurK, N5-carboxyaminoimidazole ribonucleotide synthetase, catalyzes the conversion of 5-aminoimidazole ribonucleotide ("AIR"), ATP, and bicarbonate to N5-carboxyaminoimidazole ribonucleotide ("N5-CAIR"), ADP, and Pi.
PurE, N5-carboxyaminoimidazole ribonucleotide mutase, converts N5-CAIR to CAIR, the sixth step of de novo purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. Some members of this family contain two copies of this domain.[2]
References
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External links
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Template:Carbon-carbon lyases
Template:Nucleotide metabolism enzymes
Template:InterPro content
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In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang
Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules
Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.
A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running
The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more
There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang