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| {{DISPLAYTITLE:15-hydroxyprostaglandin dehydrogenase (NADP<sup>+</sup>)}}
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| {{enzyme
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| | Name = 15-hydroxyprostaglandin dehydrogenase (NADP<sup>+</sup>)
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| | EC_number = 1.1.1.197
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| | CAS_number = 54989-39-8
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| | IUBMB_EC_number = 1/1/1/197
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| | GO_code = 0047021
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| In [[enzymology]], a '''15-hydroxyprostaglandin dehydrogenase (NADP<sup>+</sup>)''' ({{EC number|1.1.1.197}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP<sup>+</sup> <math>\rightleftharpoons</math> (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H<sup>+</sup>
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| Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate]] and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP<sup>+</sup> 15-oxidoreductase'''. Other names in common use include '''NADP<sup>+</sup>-dependent 15-hydroxyprostaglandin dehydrogenase''', '''NADP<sup>+</sup>-linked 15-hydroxyprostaglandin dehydrogenase''', '''NADP<sup>+</sup>-specific 15-hydroxyprostaglandin dehydrogenase''', '''type II 15-hydroxyprostaglandin dehydrogenase''', and '''15-hydroxyprostaglandin dehydrogenase (NADP<sup>+</sup>)'''.
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| ==Structural studies==
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| As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2PFG}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Lee SC, Levine L | date = 1975 | title = Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types | journal = J. Biol. Chem. | volume = 250 | pages = 548–52 | pmid = 234431 | issue = 2 }}
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| * {{cite journal | author = Lee SC, Pong SS, Katzen D, Wu KY, Levine L | date = 1975 | title = Distribution of prostaglandin E9-ketoreductase and types I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex | journal = Biochemistry | volume = 14 | pages = 142–5 | pmid = 803247 | doi = 10.1021/bi00672a024 | issue = 1 }}
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| [[Category:EC 1.1.1]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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| {{1.1.1-enzyme-stub}}
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