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| {{Infobox enzyme
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| | Name = Cu<sup>2+</sup>-exporting ATPase
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| | EC_number = 3.6.3.4
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| | CAS_number =
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| | IUBMB_EC_number = 3/6/3/4
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| | GO_code =
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| '''Cu<sup>2+</sup>-exporting ATPase''' ({{EC number|3.6.3.4}}) is an [[enzyme]] with system name ''ATP phosphohydrolase (Cu<sup>2+</sup>-exporting)''.<ref>{{cite journal | title = Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase |author = Vulpe, C., Levinson, B., Whitney, S., Packman, S. and Gitschier, J. |journal = Nat. Genet. |year = 1993 |volume = 3 |pages = 7–13 |pmid = 8490659 |doi=10.1038/ng0193-7 |issue=1}}</ref><ref>{{cite journal | title = Characterization of the Wilson disease gene encoding a P-type copper-transporting ATPase: genomic organization, alternative splicing, and structure/function predictions |author = Petrukhin, K., Lutsenko, S., Chernov, I., Ross, B.M., Kaplan, J.H. and Gilliam, T.C. |journal = Hum. Mol. Genet. |year = 1994 |volume = 3 |pages = 1647–1656 |pmid = 7833924 |issue=9}}</ref><ref>{{cite journal | title = P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees |author = Fagan, M.J. and Saier, M.H., Jr. |journal = J. Mol. Evol. |year = 1994 |volume = 38 |pages = 57–99 |pmid = 8151716 |issue=1}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]] | |
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| : ATP + H<sub>2</sub>O + Cu<sup>2+</sup><sub>in</sub> <math>\rightleftharpoons</math> ADP + [[phosphate]] + Cu<sup>2+</sup><sub>out</sub>
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| This [[P-type ATPase]] undergoes [[covalent]] [[phosphorylation]] during the transport cycle.
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| == References ==
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| {{reflist}}
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| == See also ==
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| * [[ATP7A]]
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| == External links ==
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| * {{MeshName|Cu2+-exporting+ATPase}}
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| [[Category:EC 3.6.3]]
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Latest revision as of 04:29, 13 January 2015
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