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| {{About|refractory periods in physiology|sexual refractory periods|refractory period (sex)}}
| | Obtaining an offshore account is one the best ways to get a person to protect their money, and something of the greatest kinds of offshore accounts are named no ID offshore account. This type of account doesn't demand a person to confirm their identification when starting the account, as well as in many situations it's properly fine for a person to open the account under a name that is diverse from their particular. There are certainly a handful of points a person should know a few zero ID offshore account like the means of starting a merchant account, and what most of these accounts usually are used for.<br><br>How exactly to open a no ID account<br><br>The method of opening up a number identification account is extremely effortless. Generally an individual can merely walk into a bank office, and then go through the procedure for opening-up a merchant account. This usually involves having someone writedown the name of the account, and then picking out what options they desire for that account. An individual can then just withdraw money from the account my writing down a key rule. Some banks offering offshore accounts will not possibly need a person to visit the financial institution workplace.<br><br>What these accounts are utilized for<br><br>These kind of accounts are often used by individuals who would like to protect their finances from things such as lawsuits, or having them removed by way of a government. This really is important, since it is one of many techniques an individual can make certain that their income just does not get taken for just about any reason. Like [http://anonymousprepaidcard1.tripod.com/ how do offshore accounts work]. |
| {{Refimprove|date=April 2013}}
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| '''Refractoriness''' is the fundamental property of any object of [[autowave]] nature (especially [[excitable medium]]) not to respond on stimuli, if the object stay in the specific ''refractory state''. In common sense, '''refractory period''' is the characteristic recovery time, a period of time that is associated with the motion of the image point on the left branch of the isocline <math>\dot{u} = 0</math><ref group="B:" name="b-Gorky-1981"/> (for more details, see also [[Reaction-diffusion]] and [[Parabolic partial differential equation]]).
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| [[Image:Action potential.svg|thumb|300px|Schematic of an [[electrophysiology|electrophysiological]] recording of an action potential showing the various phases that occur as the wave passes a point on a cell [[biological membrane|membrane]].]]
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| In [[physiology]],<ref group="B:" name="b-Schmidt-1983"/> a '''refractory period''' is a period of time during which an organ or cell is incapable of repeating a particular action, or (more precisely) the amount of time it takes for an excitable membrane to be ready for a second stimulus once it returns to its resting state following an excitation. It most commonly refers to electrically excitable muscle cells or neurons. Absolute refractory period corresponds to depolarisation and repolarisation, whereas relative refractory period corresponds to hyperpolarisation.
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| == Electrochemical usage ==
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| {{See also|Action potential}}
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| After initiation of an action potential, the refractory period is defined two ways:
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| *The '''absolute refractory period''' is the interval during which a second action potential absolutely cannot be initiated, no matter how large a stimulus is applied.
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| *The '''relative refractory period''' is the interval immediately following during which initiation of a second action potential is ''inhibited'' but not impossible.
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| The absolute refractory period coincides with nearly the entire duration of the action potential. In [[neurons]], it is caused by the '''inactivation''' of the [[Sodium channel#Role in action potential|Na<sup>+</sup> channels]] that originally opened to depolarize the membrane. These channels remain inactivated until the membrane hyperpolarizes. The channels then close, de-inactivate, and regain their ability to open in response to stimulus.
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| The relative refractory period immediately follows the absolute. As [[voltage-gated potassium channel]]s open to terminate the action potential by repolarizing the membrane, the potassium conductance of the membrane increases dramatically. K<sup>+</sup> ions moving out of the cell bring the membrane potential closer to the equilibrium potential for potassium. This causes brief hyperpolarization of the membrane, that is, the membrane potential becomes transiently more negative than the normal resting potential. Until the potassium conductance returns to the resting value, a greater stimulus will be required to reach the initiation threshold for a second depolarization. The return to the equilibrium resting potential marks the end of the relative refractory period.
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| == Cardiac refractory period ==
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| [[File:ERP.svg|thumb|right|Effective Refractory Period]]
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| The ''refractory period'' in cardiac physiology is related to the ion currents that, in cardiac cells as in nerve cells, flow into and out of the cell freely. The flow of ions translates into a change in the voltage of the inside of the cell relative to the extracellular space. As in nerve cells, this characteristic change in voltage is referred to as an action potential. Unlike that in nerve cells, the cardiac action potential duration is closer to 100 ms (with variations depending on cell type, autonomic tone, etc.). After an action potential initiates, the cardiac cell is unable to initiate another action potential for some duration of time (which is slightly shorter than the "true" action potential duration). This period of time is referred to as the refractory period, which is 250ms in length and helps to protect the heart.
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| In the classical sense, the cardiac refractory period is separated into an absolute refractory period and a relative refractory period. During the absolute refractory period, a new action potential cannot be elicited. During the relative refractory period, a new action potential can be elicited under the correct circumstances.
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| The cardiac refractory period can result in different type of ''re-entry'', which is considered as a main cause of many kinds of tachycardia.<ref group="A:" name="a-Wiener-1946"/><ref group="B:" name="b-Ardashev-2009p06"/> As a sort of ''re-entry'', the vortices of excitation in the myocardium ([[Autowave|autowave vortices]]) is considered to be the main mechanism of life-threatening cardiac arrhythmias. In particular, the [[autowave reverberator]] is a typical in thin walls of the atria, with the auricular flutter producing.
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| == Neuronal refractory period ==
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| The '''refractory period in a [[neuron]]''' occurs after an [[action potential]] and generally lasts one millisecond. An action potential consists of three phases.
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| Phase one is depolarization. During depolarization, voltage-gated sodium ion channels open, increasing the neuron's membrane conductance for sodium ions and depolarizing the cell's membrane potential (from typically -70 mV toward a positive potential). In other words, the membrane is made less negative. After the potential reaches the activation threshold (-55 mV), the depolarization is actively driven by the neuron and overshoots the equilibrium potential of an activated membrane (+30 mV).
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| Phase two is repolarization. During repolarization, voltage-gated sodium ion channels inactivate (different from the close state) due to the now-depolarized membrane, and voltage-gated potassium channels activate (open). Both the inactivation of the sodium ion channels and the opening of the potassium ion channels act to repolarize the cell's membrane potential back to its resting membrane potential.
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| When the cell's membrane voltage overshoots its resting membrane potential (near -60mV), the cell enters a phase of hyperpolarization. This is due to a larger-than-resting potassium conductance across the cell membrane. This potassium conductance eventually drops and the cell returns to its resting membrane potential.
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| The refractory periods are due to the inactivation property of voltage-gated sodium channels and the lag of potassium channels in closing. Voltage-gated sodium channels have two gating mechanisms, the activation mechanism that opens the channel with depolarization and the inactivation mechanism that closes the channel with repolarization. While the channel is in the inactive state, it will not open in response to depolarization. The period when the majority of sodium channels remain in the inactive state is the absolute refractory period. After this period, there are enough voltage-activated sodium channels in the closed (active) state to respond to depolarization. However, voltage-gated potassium channels that opened in response to depolarization do not close as quickly as voltage-gated sodium channels return to the active closed state. During this time, the extra potassium conductance means that the membrane is at a higher threshold and will require a greater stimulus to cause action potentials to fire. This period is the relative refractory period.
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| == See also ==
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| {{Div col}}
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| * [[Autowave]]
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| * [[Excitable medium]]
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| * [[Parabolic partial differential equation]]
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| * [[Reaction-diffusion]]
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| {{Div col end}}
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| == Notes ==
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| <!-- {{notelist}} -->
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| == References ==
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| * Books
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| {{Reflist
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| | group = "B:"
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| | refs =
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| <ref name="b-Gorky-1981">{{cite book
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| |last1 =
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| |first1 =
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| |authorlink1 =
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| |title = Автоволновые процессы в системах с диффузией
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| |trans_title = Autowave processes in systems with diffusion
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| |url =
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| | editor-last = Грехова
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| | editor-first = М. Т.
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| | editor-link =
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| |location = Горький
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| |publisher = Институт прикладной математики АН СССР
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| |year = 1981
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| |pages = 287
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| |language = ru
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| |isbn =
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| }}</ref>
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| <ref name="b-Ardashev-2009p06">{{cite book
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| |last1 = Елькин
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| |first1 = Ю.Е.
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| |authorlink1 =
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| |last2 = Москаленко
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| |first2 = А.В.
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| |authorlink2 =
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| |chapter = Базовые механизмы аритмий сердца
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| |trans_chapter = Basic mechanisms of cardiac arrhythmias
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| |chapterurl = http://books.avmoskalenko.ru/lRus/y2009a/index.htm
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| |title = Клиническая аритмология
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| |trans_title = Clinical arrhythmology
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| |url = http://ardashev-arrhythmia.ru/publications/books/klinicheskaya-aritmologiya/
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| |editor-last = Ardashev
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| |editor-first = prof. {{nobr|A.V.}}
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| |editor-link = http://ardashev-arrhythmia.ru/
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| |location = Moscow
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| |publisher = MedPraktika
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| |year = 2009
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| |pages = 1220
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| |language = ru
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| |isbn = 978-5-98803-198-7
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| }}</ref>
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| <ref name="b-Schmidt-1983">{{cite book
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| |last1 = Schmidt
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| |first1 = Robert F.
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| |authorlink1 =
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| |last2 = Thews
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| |first2 = Gerhard
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| |authorlink2 =
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| |chapter =
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| |trans_chapter =
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| |chapterurl =
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| |title = Human physiology
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| |trans_title =
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| |url =
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| |editor-last =
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| |editor-first =
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| |editor-link =
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| |location =
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| |publisher = Springer-Verlag
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| |year = 1983
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| |pages = 725
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| |isbn = 978-3540116691
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| }}</ref>
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| <-- ref name="b-a-2009">a-2009…</ref -->
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| }}
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| * Papers
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| {{Reflist
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| | group = "A:"
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| | refs =
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| <ref name="a-Wiener-1946">{{cite journal
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| |last1 = Wiener
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| |first1 = N.
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| |authorlink1 =
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| |last2 = Rosenblueth
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| |first2 = A.
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| |authorlink2 =
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| |title = The mathimatical formulation of the problem of conduction of impulses in a network of connected exitable elements, specifically in cardiac muscle
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| |url =
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| |journal = Arch. Inst. Cardiologia de Mexico
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| |type = journal
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| |year = 1946
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| |volume = 16
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| |issue = 3—4
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| |pages = 205–265
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| |doi =
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| |issn =
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| }}</ref>
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| <-- ref name="a-a-2009">a-2009…</ref -->
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| }}
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| {{DEFAULTSORT:Refractory Period (Physiology)}}
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| [[Category:Physiology]]
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| [[Category:Cardiac electrophysiology]]
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| [[Category:Neurophysiology]]
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| [[ar:دور الحران]]
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| [[bg:Рефрактерен период]]
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| [[fr:Période réfractaire (physiologie)]]
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| [[lt:Refrakcinis laikotarpis]]
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| [[nl:Refractaire periode]]
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| [[pl:Refrakcja (elektrofizjologia)]]
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| [[ru:Рефрактерный период]]
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Obtaining an offshore account is one the best ways to get a person to protect their money, and something of the greatest kinds of offshore accounts are named no ID offshore account. This type of account doesn't demand a person to confirm their identification when starting the account, as well as in many situations it's properly fine for a person to open the account under a name that is diverse from their particular. There are certainly a handful of points a person should know a few zero ID offshore account like the means of starting a merchant account, and what most of these accounts usually are used for.
How exactly to open a no ID account
The method of opening up a number identification account is extremely effortless. Generally an individual can merely walk into a bank office, and then go through the procedure for opening-up a merchant account. This usually involves having someone writedown the name of the account, and then picking out what options they desire for that account. An individual can then just withdraw money from the account my writing down a key rule. Some banks offering offshore accounts will not possibly need a person to visit the financial institution workplace.
What these accounts are utilized for
These kind of accounts are often used by individuals who would like to protect their finances from things such as lawsuits, or having them removed by way of a government. This really is important, since it is one of many techniques an individual can make certain that their income just does not get taken for just about any reason. Like how do offshore accounts work.