2-hydroxyglutarate synthase: Difference between revisions

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{{enzyme
| Name = 8-amino-7-oxononanoate synthase
| EC_number = 2.3.1.47
| CAS_number = 9075-61-0
| IUBMB_EC_number = 2/3/1/47
| GO_code = 0008710
| image =
| width =
| caption =
}}
In [[enzymology]], a '''8-amino-7-oxononanoate synthase''' ({{EC number|2.3.1.47}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:6-carboxyhexanoyl-CoA + L-alanine <math>\rightleftharpoons</math> 8-amino-7-oxononanoate + CoA + CO<sub>2</sub>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[6-carboxyhexanoyl-CoA]] and [[L-alanine]], whereas its 3 [[product (chemistry)|products]] are [[8-amino-7-oxononanoate]], [[coenzyme A|CoA]], and [[carbon dioxide|CO<sub>2</sub>]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is '''6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)'''. Other names in common use include '''7-keto-8-aminopelargonic acid synthetase''', '''7-keto-8-aminopelargonic synthetase''', and '''8-amino-7-oxopelargonate synthase'''. This enzyme participates in [[biotin metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[pyridoxal phosphate]].
 
==Structural studies==
 
As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1BS0}}, {{PDB link|1DJ9}}, {{PDB link|1DJE}}, and {{PDB link|2G6W}}.
 
==References==
{{reflist|1}}
 
{{refbegin}}
* {{cite journal | author = Eisenberg MA, Star C | date = 1968 | title = Synthesis of 7-Oxo-8-Aminopelargonic Acid, a Biotin Vitamer, in Cell-free Extracts of Escherichia coli Biotin Auxotrophs | journal = J. Bacteriol. | volume = 96 | pages = 1291&ndash;7  | pmid = 4879561 | issue = 4 | pmc = 252447 }}
* {{cite journal | author = L | date = 1998 | title = The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme | journal = J. Mol. Biol. | volume = 284 | pages = 401&ndash;19  | pmid = 9813126 | doi = 10.1006/jmbi.1998.2086 | last2 = Alexeeva | first2 = M | last3 = Baxter | first3 = RL | last4 = Campopiano | first4 = DJ | last5 = Webster | first5 = SP | last6 = Sawyer | first6 = L | issue = 2 }}
* {{cite journal | author = Ploux O, Breyne O, Carillon S, Marquet A | date = 1999 | title = Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies | journal = Eur. J. Biochem| volume = 259 | pages = 63&ndash;70  | pmid = 9914476 | doi = 10.1046/j.1432-1327.1999.00006.x | issue = 1–2 }}
* {{cite journal | author = Baxter RL | date = 2000 | title = Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies | journal = Biochemistry. | volume = 39 | pages = 516&ndash;28  | pmid = 10642176 | doi = 10.1021/bi991620j | last2 = Alexeev | first2 = D | last3 = Campopiano | first3 = DJ | last4 = Watt | first4 = RM | last5 = Alexeeva | first5 = M | last6 = Sawyer | first6 = L | last7 = Baxter | first7 = RL | issue = 3 }}
{{refend}}
 
{{transferase-stub}}
 
[[Category:EC 2.3.1]]
[[Category:Pyridoxal phosphate enzymes]]
[[Category:Enzymes of known structure]]

Latest revision as of 21:41, 17 March 2013

Template:Enzyme In enzymology, a 8-amino-7-oxononanoate synthase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

6-carboxyhexanoyl-CoA + L-alanine 8-amino-7-oxononanoate + CoA + CO2

Thus, the two substrates of this enzyme are 6-carboxyhexanoyl-CoA and L-alanine, whereas its 3 products are 8-amino-7-oxononanoate, CoA, and CO2.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating). Other names in common use include 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, and 8-amino-7-oxopelargonate synthase. This enzyme participates in biotin metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

Template:Refbegin

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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  • One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

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