(S)-stylopine synthase: Difference between revisions

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{{enzyme
| Name = taxadiene 5-alpha-hydroxylase
| EC_number = 1.14.99.37
| CAS_number = 9035-51-2
| IUBMB_EC_number = 1/14/99/37
| GO_code = 0050604
| image =
| width =
| caption =
}}
In [[enzymology]], a '''taxadiene 5alpha-hydroxylase''' ({{EC number|1.14.99.37}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:taxa-4,11-diene + AH<sub>2</sub> + O<sub>2</sub> <math>\rightleftharpoons</math> taxa-4(20),11-dien-5alpha-ol + A + H<sub>2</sub>O


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The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[taxa-4,11-diene]], an [[electron acceptor]] AH<sub>2</sub>, and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[taxa-4(20),11-dien-5alpha-ol]], the reduction product A, and [[water|H<sub>2</sub>O]].
 
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is '''taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)'''. This enzyme participates in [[diterpenoid biosynthesis]].
 
==References==
{{reflist|1}}
* {{cite journal | author = R | date = 1996 | title = Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis | journal = Chem. Biol| volume = 3 | pages = 479&ndash;89  | pmid = 8807878 | doi = 10.1016/S1074-5521(96)90096-4 | last2 = Rubenstein | first2 = SM | last3 = Ketchum | first3 = RE | last4 = Gibson | first4 = DM | last5 = Williams | first5 = RM | last6 = Croteau | first6 = R | issue = 6 }}
 
{{1.14-enzyme-stub}}
 
[[Category:EC 1.14.99]]
[[Category:Enzymes of unknown structure]]

Latest revision as of 02:46, 2 March 2013

Template:Enzyme In enzymology, a taxadiene 5alpha-hydroxylase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

taxa-4,11-diene + AH2 + O2 taxa-4(20),11-dien-5alpha-ol + A + H2O

The 3 substrates of this enzyme are taxa-4,11-diene, an electron acceptor AH2, and O2, whereas its 3 products are taxa-4(20),11-dien-5alpha-ol, the reduction product A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating). This enzyme participates in diterpenoid biosynthesis.

References

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