188.221.222.206: /* Government Working Group */ Removed reference to MMP Tax as not important.

2013-09-20T20:05:58Z

Government Working Group: Removed reference to MMP Tax as not important.

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{{Infobox enzyme
| Name = Limonene-1,2-diol dehydrogenase
| EC_number = 1.1.1.297
| CAS_number =
| IUBMB_EC_number = 1/1/1/297
| GO_code =
| image =
| width =
| caption =
}}
'''Limonene-1,2-diol dehydrogenase''' ({{EC number|1.1.1.297}}, ''NAD+-dependent limonene-1,2-diol dehydrogenase'') is an [[enzyme]] with system name ''menth-8-ene-1,2-diol:NAD+ oxidoreductase''.<ref>{{cite journal | title = Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene |author = van der Werf, M.J., Swarts, H.J. and de Bont, J.A. |journal = Appl. Environ. Microbiol. |date = 1999 |volume = 65 |pages = 2092–2102 |pmid = 10224006 | issue = 5 | pmc = 91303}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: menth-8-ene-1,2-diol + NAD+ <math>\rightleftharpoons</math> 1-hydroxymenth-8-en-2-one + NADH + H+ (general reaction)
:(1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD+ <math>\rightleftharpoons</math> (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H+
:(2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD+ <math>\rightleftharpoons</math> (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H+

While the enzyme from the Gram-positive bacterium ''[[Rhodococcus erythropolis]]'' DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Limonene-1,2-diol+dehydrogenase}}

[[Category:EC 1.1.1]]

Patent Box - Revision history

188.221.222.206: /* Government Working Group */ Removed reference to MMP Tax as not important.