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{{enzyme
| Name = nucleotide diphosphatase
| EC_number = 3.6.1.9
| CAS_number = 9032-64-8
| IUBMB_EC_number = 3/6/1/9
| GO_code = 0004551
| image =
| width =
| caption =
}}
In [[enzymology]], a '''nucleotide diphosphatase''' ({{EC number|3.6.1.9}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:a dinucleotide + H<sub>2</sub>O <math>\rightleftharpoons</math> 2 mononucleotides

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[dinucleotide]] and [[water|H<sub>2</sub>O]], whereas its [[product (chemistry)|product]] is [[Nucleotide|mononucleotide]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is '''dinucleotide nucleotidohydrolase'''. Other names in common use include '''nucleotide pyrophosphatase''', and '''nucleotide-sugar pyrophosphatase'''. This enzyme participates in 5 [[metabolism|metabolic pathways]]: [[purine metabolism]], [[starch and sucrose metabolism]], [[riboflavin metabolism]], [[nicotinate and nicotinamide metabolism]], and [[pantothenate and coa biosynthesis]].

==Structural studies==

{{As of|2007|alt=As of late 2007}}, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1NQY}}, {{PDB link|1NQZ}}, {{PDB link|2GSN}}, {{PDB link|2GSO}}, and {{PDB link|2GSU}}.

==References==
{{reflist|1}}
* {{cite journal | author = Jacobson JB and Kaplan NO | date = 1957 | title = A reduced pyridine nucleotide pyrophosphatase | journal = J. Biol. Chem. | volume = 226 | pages = 427–437 | pmid=13428775}}
* {{cite journal | author = Kornberg A and Pricer WE | date = 1950 | title = Nucleotide pyrophosphatase | journal = J. Biol. Chem. | volume = 182 | pages = 763–778 }}
* {{cite journal | author = Kumar SA, Rao NA, Vaidyanathan CS | date = 1965 | title = Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus) | journal = Arch. Biochem. Biophys. | volume = 111 | pages = 646–52 | pmid = 5862212 | doi = 10.1016/0003-9861(65)90246-8 | issue = 3 }}
* {{cite journal | author = Swartz MN, Kaplan NO and Lamborg MF | date = 1958 | title = A "heat-activated" diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris | journal = J. Biol. Chem. | volume = 232 | pages = 1051–1063 | pmid=13549486}}

{{hydrolase-stub}}

[[Category:EC 3.6.1]]
[[Category:Enzymes of known structure]]

Nucleoside-diphosphatase - Revision history

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