en>David Eppstein: Fix incoming links, remove orphan tag

2013-11-28T01:23:47Z

Fix incoming links, remove orphan tag

← Older revision		Revision as of 03:23, 28 November 2013
Line 1:		Line 1:
	~~Nice~~ to ~~satisfy you~~, ~~my name~~ is ~~Ling and I totally dig that name~~. ~~The occupation he~~'~~s been occupying for years~~ is a ~~messenger~~. The ~~favorite pastime for him~~ and ~~his kids is~~ to ~~perform badminton but he is having difficulties~~ to ~~discover time for it~~. ~~Delaware~~ is ~~our beginning location~~.<br><br>~~Also visit my website :: [~~http://~~Rulecubed~~.~~com~~/~~blogs~~/~~post~~/~~9981 rulecubed.com~~]		{{enzyme
			\| Name = Dihydroorotate oxidase
			\| EC_number = 1.3.3.1
			\| CAS_number = 9029-03-2
			\| IUBMB_EC_number = 1/3/3/1
			\| GO_code = 000415
			\| image =
			\| width =
			\| caption =
			}}
			{{Pfam_box
			\| Symbol = DHO_dh
			\| Name =
			\| image =1f76.gif
			\| width =
			\| caption =Dihydroorotate dehydrogenase from ''E. coli''
			\| Pfam= PF01180
			\| InterPro= IPR001295
			\| SMART=
			\| PROSITE = PDOC00708
			\| SCOP = 1dor
			\| TCDB =
			\| OPM family= 59
			\| OPM protein= 1uum
			\| PDB=
			{{PDB3\|1f76}}A:47-336 {{PDB3\|1uum}}A:77-377 {{PDB3\|1uuo}}A:77-377
			{{PDB3\|1d3g}}A:77-377 {{PDB3\|1d3h}}A:77-377 {{PDB3\|2b0m}}A:77-377
			{{PDB3\|1lx3}}A:49-334 {{PDB3\|1tv5}}A:207-550 {{PDB3\|1ep3}}A:6-291
			{{PDB3\|1ep2}}A:6-291 {{PDB3\|1ep1}}A:6-291 {{PDB3\|1h7x}}A:532-838
			{{PDB3\|1gte}}A:532-838 {{PDB3\|1h7w}}B:532-838 {{PDB3\|1gth}}A:532-838
			{{PDB3\|1gt8}}A:532-838 {{PDB3\|1jue}}A:1-293 {{PDB3\|1jrb}}A:1-293
			{{PDB3\|1jub}}A:1-293 {{PDB3\|1jqx}}A:1-293 {{PDB3\|1jrc}}B:1-293
			{{PDB3\|2dor}}A:1-293 {{PDB3\|1nfc}}A:1-293 {{PDB3\|1jqv}}B:1-293
			{{PDB3\|1ovd}}B:1-293 {{PDB3\|1dor}}A:1-293 {{PDB3\|2b4g}}D:2-294
			}}
			{{protein
			\|Name=Human dihydroorotate dehydrogenase
			\|caption=
			\|image=
			\|width=
			\|HGNCid=2867
			\|Symbol=DHODH
			\|AltSymbols=
			\|EntrezGene=1723
			\|OMIM=126064
			\|RefSeq=NM_001361
			\|UniProt=Q02127
			\|PDB=1D3G
			\|ECnumber=1.3.3.1
			\|Chromosome=16
			\|Arm=q
			\|Band=22
			\|LocusSupplementaryData=
			}}

			'''Dihydroorotate dehydrogenase''' ({{EC number\|1.3.3.1}}) is an [[enzyme]] that catalyzes the fourth step in the ''de novo'' [[pyrimidine biosynthesis\|biosynthesis of pyrimidine]]. It converts [[dihydroorotate]] to [[orotate]]:

			: (S)-dihydroorotate + O<sub>2</sub> <math>\rightleftharpoons</math> orotate + H<sub>2</sub>O<sub>2</sub>

			<gallery>
			Image:4,5-Dihydroorotic acid.svg\|[[4,5-Dihydroorotic acid]]
			Image:Orotic-acid-2D-skeletal.png\|[[Orotic acid]]. Note the double bond in the ring.
			</gallery>

			Human dihydroorotate dehydrogenase is a ubiquitous [[Flavin mononucleotide\|FMN]] [[flavoprotein]]. In bacteria (gene pyrD), it is located on the inner side of the [[cell membrane\|cytosolic membrane]]. In some yeasts, such as in ''[[Saccharomyces cerevisiae]]'' (gene URA1), it is a cytosolic protein, whereas, in other eukaryotes, it is found in the mitochondria.<ref name="PUB00004801">{{cite journal \|author=Lacroute F, Thomas D, Nagy M \|title=Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts \|journal=Proc. Natl. Acad. Sci. U.S.A. \|volume=89 \|issue=19 \|pages=8966–70 \|year=1992 \|pmid=1409592 \|doi=10.1073/pnas.89.19.8966 \|pmc=50045}}</ref>

			==Human proteins containing this domain ==
			[[DHODH]]; [[DPYD]];

			==Clinical significance==
			The anti-inflammatory drug [[leflunomide]] has been shown to inhibit DHODH. Human DHODH has two domains: an alpha/beta-barrel domain containing the active site and an alpha-helical domain that forms the opening of a tunnel leading to the active site. Leflunomide has been shown to bind in this tunnel.<ref name="pmid10673429">{{cite journal \| author = Liu S, Neidhardt EA, Grossman TH, Ocain T, Clardy J \| title = Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents \| journal = Structure \| volume = 8 \| issue = 1 \| pages = 25–33 \|date=January 2000 \| pmid = 10673429 \| doi = 10.1016/S0969-2126(00)00077-0 \| url = }}</ref> Leflunomide is being used for treatment of rheumatoid and psoriatic arthritis.

			Mutations in this gene have been shown to cause [[Miller syndrome]] <ref name="pmid19915526">{{cite journal \| author = Ng SB, Buckingham KJ,Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ \| title = Exome Sequencing identifies the cause of a mendelian disorder \| journal = Nature Genetics \| volume = 42 \| issue = 1 \| pages = 30–5 \|date=December 2009 \| pmid = 19915526 \| doi = 10.1038/ng.499 \| pmc = 2847889 }}</ref> also known as Genee-Wiedemann syndrome, Wildervanck-Smith syndrome or post axial acrofacial dystosis (POADS).

			==References==
			{{reflist}}

			==Further reading==
			{{refbegin}}

			* {{cite journal \| author = Rowland P, Björnberg O, Nielsen FS, Jensen KF, Larsen S \| title = The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function \| journal = Protein Sci. \| volume = 7 \| issue = 6 \| pages = 1269–79 \|date=June 1998 \| pmid = 9655329 \| pmc = 2144028 \| doi = 10.1002/pro.5560070601\| url = http://www.proteinscience.org/cgi/content/abstract/7/6/1269 }}
			{{refend}}

			==External links==
			* {{MeshName\|dihydroorotate+dehydrogenase}}

			{{CH-CH oxidoreductases}}
			{{Nucleotide metabolism}}
			{{Mitochondrial enzymes}}

			{{InterPro content\|IPR001295}}

			{{DEFAULTSORT:Dihydroorotate Dehydrogenase}}
			[[Category:Protein domains]]
			[[Category:Peripheral membrane proteins]]


			{{oxidoreductase-stub}}

en>CRGreathouse: wording

2012-02-06T14:12:09Z

wording

New page

Nice to satisfy you, my name is Ling and I totally dig that name. The occupation he's been occupying for years is a messenger. The favorite pastime for him and his kids is to perform badminton but he is having difficulties to discover time for it. Delaware is our beginning location.<br><br>Also visit my website :: [http://Rulecubed.com/blogs/post/9981 rulecubed.com]

Frobenius matrix - Revision history

en>David Eppstein: Fix incoming links, remove orphan tag

en>CRGreathouse: wording