en>Citation bot 1: Citations: [Pu162]Tweaked: issue. You can use this bot yourself! Report bugs here.

2010-06-10T06:15:14Z

Citations: [Pu162]Tweaked: issue. You can use this bot yourself! Report bugs here.

New page

{{enzyme
| Name = N2-(2-carboxyethyl)arginine synthase
| EC_number = 2.5.1.66
| CAS_number =
| IUBMB_EC_number = 2/5/1/66
| GO_code =
| image =
| width =
| caption =
}}
In [[enzymology]], a '''N2-(2-carboxyethyl)arginine synthase''' ({{EC number|2.5.1.66}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:D-glyceraldehyde 3-phosphate + L-arginine <math>\rightleftharpoons</math> N<sub>2</sub>-(2-carboxyethyl)-L-arginine + phosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[D-glyceraldehyde 3-phosphate]] and [[L-arginine]], whereas its two [[product (chemistry)|products]] are [[N2-(2-carboxyethyl)-L-arginine]] and [[phosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is '''glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)'''. Other names in common use include '''CEAS''', '''N2-(2-carboxyethyl)arginine synthetase''', '''CEA synthetase''', '''glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl)''', and '''transferase (2-carboxyethyl-forming)'''. This enzyme participates in [[clavulanic acid biosynthesis]].

==Structural studies==

As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2IHT}} and {{PDB link|2IHV}}.

==References==
{{reflist|1}}
* {{cite journal | author = Caines ME, Elkins JM, Hewitson KS, Schofield CJ | date = 2004 | title = Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway | journal = J. Biol. Chem. | volume = 279 | pages = 5685–92 | pmid = 14623876 | doi = 10.1074/jbc.M310803200 | issue = 7 }}
* {{cite journal | author = Khaleeli N, Li R and Townsend CA | date = 1999 | title = Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction | journal = J. Am. Chem. Soc. | volume = 121 | issue = 39 | pages = 9223–9224 | doi = 10.1021/ja9923134 }}

{{transferase-stub}}

[[Category:EC 2.5.1]]
[[Category:Enzymes of known structure]]

Discadenine synthase - Revision history

en>Citation bot 1: Citations: [Pu162]Tweaked: issue. You can use this bot yourself! Report bugs here.