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{{enzyme
| Name = CDP-glucose 4,6-dehydratase
| EC_number = 4.2.1.45
| CAS_number = 37259-55-5
| IUBMB_EC_number = 4/2/1/45
| GO_code = 0047733
| image =
| width =
| caption =
}}
In the field of [[enzymology]], a '''CDP-glucose 4,6-dehydratase''' is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:[[Cytidine diphosphate glucose|CDP-glucose]] <math>\rightleftharpoons</math> CDP-4-dehydro-6-deoxy-D-glucose + H<sub>2</sub>O

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[cytidine diphosphate glucose|CDP-glucose]], and two [[product (chemistry)|products]], CDP-4-dehydro-6-deoxy-D-glucose and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[lyase]]s, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in starch and sucrose [[metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[Nicotinamide adenine dinucleotide|NAD+]].

== Nomenclature ==
The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include:
* cytidine diphosphoglucose oxidoreductase, and
* CDP-glucose 4,6-hydro-lyase.

==Structural studies==

As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1RKX}} and {{PDB link|1WVG}}.

==References==
{{reflist|1}}
* {{cite journal | author = Hey AE, Elbein AD | date = 1966 | title = Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase | journal = J. Biol. Chem. | volume = 241 | pages = 5473–8 | pmid = 4380946 | issue = 22 }}
* {{cite journal | author = Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL | date = 1966 | title = Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase | journal = J. Biol. Chem. | volume = 241 | pages = 4283–7 | pmid = 4288651 | issue = 18 }}
* {{cite journal | author = Melo A, Elliott WH, Glaser L | date = 1968 | title = The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase | journal = J. Biol. Chem. | volume = 243 | pages = 1467–74 | pmid = 4869560 | issue = 7 }}

{{4.2-enzyme-stub}}

[[Category:EC 4.2.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of known structure]]

Arabinonate dehydratase - Revision history

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