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<p><b>New page</b></p><div>{{enzyme<br />
| Name = ADP-dependent short-chain-acyl-CoA hydrolase<br />
| EC_number = 3.1.2.18<br />
| CAS_number = 117698-16-5<br />
| IUBMB_EC_number = 3/1/2/18<br />
| GO_code = 0047379<br />
| image = <br />
| width = <br />
| caption = <br />
}}<br />
In [[enzymology]], an '''ADP-dependent short-chain-acyl-CoA hydrolase''' ({{EC number|3.1.2.18}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]<br />
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:acyl-CoA + H<sub>2</sub>O <math>\rightleftharpoons</math> CoA + a carboxylate<br />
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[acyl-CoA]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[coenzyme A|CoA]] and [[carboxylate]].<br />
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This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on [[thioester]] bonds. The systematic name of this enzyme class is '''ADP-dependent-short-chain-acyl-CoA hydrolase'''. Other names in common use include '''short-chain acyl coenzyme A hydrolase''', '''propionyl coenzyme A hydrolase''', '''propionyl-CoA hydrolase''', '''propionyl-CoA thioesterase''', '''short-chain acyl-CoA hydrolase''', and '''short-chain acyl-CoA thioesterase'''. It employs one [[cofactor (biochemistry)|cofactor]], [[Adenosine diphosphate|ADP]]. At least one compound, [[NADH]] is known to [[enzyme inhibitor|inhibit this enzyme]]. <br />
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==References==<br />
{{reflist|1}}<br />
* {{cite journal | author = Alexson SE, Nedergaard J | date = 1988 | title = A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria | journal = J. Biol. Chem. | volume = 263 | pages = 13564&ndash;71 | pmid = 2901416 | issue = 27 }}<br />
* {{cite journal | author = Alexson SE, Svensson LT, Nedergaard J | date = 1989 | title = NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat | journal = Biochim. Biophys. Acta. | volume = 1005 | pages = 13&ndash;9 | pmid = 2570608 | issue = 1 }}<br />
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{{hydrolase-stub}}<br />
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[[Category:EC 3.1.2]]<br />
[[Category:Enzymes of unknown structure]]</div>en>Citation bot