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2,5-didehydrogluconate reductase - Revision history
2026-04-24T20:32:06Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:34, 29 May 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Alyson Meagher is the name her parents gave her but she doesn</del>'<del style="font-weight: bold; text-decoration: none;">t like when people use her full title. For a while I</del>'<del style="font-weight: bold; text-decoration: none;">ve been in Mississippi but now I</del>'<del style="font-weight: bold; text-decoration: none;">m contemplating other choices</del>. <del style="font-weight: bold; text-decoration: none;">Office supervising is exactly where my primary earnings comes from but I've always wanted my own business</del>. <del style="font-weight: bold; text-decoration: none;">To climb </del>is <del style="font-weight: bold; text-decoration: none;">some thing I truly appreciate doing.</del><<del style="font-weight: bold; text-decoration: none;">br</del>><<del style="font-weight: bold; text-decoration: none;">br</del>><del style="font-weight: bold; text-decoration: none;">Also [http:</del>//<del style="font-weight: bold; text-decoration: none;">bigpolis.com</del>/<del style="font-weight: bold; text-decoration: none;">blogs/post/6503 online psychic readings</del>] <del style="font-weight: bold; text-decoration: none;">visit my webpage online </del>[<del style="font-weight: bold; text-decoration: none;">http://checkmates.co.za/index.php?do=/profile</del>-<del style="font-weight: bold; text-decoration: none;">56347/info/ psychic chat online</del>] <del style="font-weight: bold; text-decoration: none;">chat</del>, [<del style="font-weight: bold; text-decoration: none;">http:</del>/<del style="font-weight: bold; text-decoration: none;">/medialab</del>.<del style="font-weight: bold; text-decoration: none;">zendesk.com</del>/<del style="font-weight: bold; text-decoration: none;">entries</del>/<del style="font-weight: bold; text-decoration: none;">54181460</del>-<del style="font-weight: bold; text-decoration: none;">Will</del>-<del style="font-weight: bold; text-decoration: none;">You</del>-<del style="font-weight: bold; text-decoration: none;">Often</del>-<del style="font-weight: bold; text-decoration: none;">End</del>-<del style="font-weight: bold; text-decoration: none;">Up</del>-<del style="font-weight: bold; text-decoration: none;">Bored</del>-<del style="font-weight: bold; text-decoration: none;">Try</del>-<del style="font-weight: bold; text-decoration: none;">One-Of</del>-<del style="font-weight: bold; text-decoration: none;">These</del>-<del style="font-weight: bold; text-decoration: none;">Hobby-Ideas- related internet page],</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{enzyme</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| Name = 2-deoxy-D-gluconate 3-dehydrogenase</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| EC_number = 1.1.1.125</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| CAS_number = 37250-54-7</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| IUBMB_EC_number = 1/1/1/125</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| GO_code = 0008678</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| image = </ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| caption = </ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">}}</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''2-deoxy-D-gluconate 3-dehydrogenase</ins>''' <ins style="font-weight: bold; text-decoration: none;">({{EC number|1.1</ins>.<ins style="font-weight: bold; text-decoration: none;">1</ins>.<ins style="font-weight: bold; text-decoration: none;">125}}) </ins>is <ins style="font-weight: bold; text-decoration: none;">an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:2-deoxy-D-gluconate + NAD</ins><<ins style="font-weight: bold; text-decoration: none;">sup</ins>><ins style="font-weight: bold; text-decoration: none;">+</ins><<ins style="font-weight: bold; text-decoration: none;">/sup</ins>> <ins style="font-weight: bold; text-decoration: none;"><math>\rightleftharpoons<</ins>/<ins style="font-weight: bold; text-decoration: none;">math> 3-dehydro-2-deoxy-D-gluconate + NADH + H<sup>+<</ins>/<ins style="font-weight: bold; text-decoration: none;">sup></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[2-deoxy-D-gluconate]] and [[nicotinamide adenine dinucleotide|NAD<sup>+<</ins>/<ins style="font-weight: bold; text-decoration: none;">sup>]], whereas its 3 [[product (chemistry)|products]</ins>] <ins style="font-weight: bold; text-decoration: none;">are [</ins>[<ins style="font-weight: bold; text-decoration: none;">3-dehydro-2-deoxy-D</ins>-<ins style="font-weight: bold; text-decoration: none;">gluconate]], [[nicotinamide adenine dinucleotide|NADH]</ins>], <ins style="font-weight: bold; text-decoration: none;">and [</ins>[<ins style="font-weight: bold; text-decoration: none;">hydrogen ion|H<sup>+<</ins>/<ins style="font-weight: bold; text-decoration: none;">sup>]]</ins>.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+<</ins>/<ins style="font-weight: bold; text-decoration: none;">sup> or NADP<sup>+<</ins>/<ins style="font-weight: bold; text-decoration: none;">sup> as acceptor. The systematic name of this enzyme class is '''2</ins>-<ins style="font-weight: bold; text-decoration: none;">deoxy</ins>-<ins style="font-weight: bold; text-decoration: none;">D</ins>-<ins style="font-weight: bold; text-decoration: none;">gluconate:NAD<sup>+</sup> 3</ins>-<ins style="font-weight: bold; text-decoration: none;">oxidoreductase'''. This enzyme is also called '''2</ins>-<ins style="font-weight: bold; text-decoration: none;">deoxygluconate dehydrogenase'''. This enzyme participates in [[pentose and glucuronate interconversions]].</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Structural studies==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1X1E}}.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==References==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{reflist|1}}</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* {{cite journal | author = Eichhorn MM and Cynkin MA | year = 1965 | title = Microbial metabolism of 2</ins>-<ins style="font-weight: bold; text-decoration: none;">deoxyglucose; 2</ins>-<ins style="font-weight: bold; text-decoration: none;">deoxyglucose acid dehydrogenase | journal = Biochemistry | volume = 4 | pages = 159&ndash;165 | doi = 10.1021/bi00877a024 | pmid=14285233}}</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:EC 1.1.1]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:NADH</ins>-<ins style="font-weight: bold; text-decoration: none;">dependent enzymes]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Enzymes of known structure]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{1.1.1</ins>-<ins style="font-weight: bold; text-decoration: none;">enzyme</ins>-<ins style="font-weight: bold; text-decoration: none;">stub}}</ins></div></td></tr>
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