View source for TRNA (adenine9-N1)-methyltransferase

{{Infobox enzyme
| Name = TRNA (carboxymethyluridine<sup>34</sup>-5-O)-methyltransferase
| EC_number = 2.1.1.229
| CAS_number = 
| IUBMB_EC_number = 2/1/1/229
| GO_code = 
| image = 
| width = 
| caption =
}}
'''TRNA (carboxymethyluridine<sup>34</sup>-5-O)-methyltransferase''' ({{EC number|2.1.1.229}}, ''ALKBH8'', ''ABH8'', ''Trm9'', ''tRNA methyltransferase 9'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:tRNA (carboxymethyluridine<sup>34</sup>-5-O)-methyltransferase''.<ref>{{cite journal | title = Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival |author = Fu, D., Brophy, J.A., Chan, C.T., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J. and Samson, L.D. |journal = Mol. Cell Biol. |date = 2010 |volume = 30 |pages = 2449-2459 |pmid = 20308323}}</ref><ref>{{cite journal | title = Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding |author = Songe-M&oslash;ller, L., van den Born, E., Leihne, V., V&aring;gb&oslash;, C.B., Kristoffersen, T., Krokan, H.E., Kirpekar, F., Falnes, P.&Oslash;. and Klungland, A. |journal = Mol. Cell Biol. |date = 2010 |volume = 30 |pages = 1814-1827 |pmid = 20123966}}</ref><ref>{{cite journal | title = Novel methyltransferase for modified uridine residues at the wobble position of tRNA |author = Kalhor, H.R. and Clarke, S. |journal = Mol. Cell Biol. |date = 2003 |volume = 23 |pages = 9283-9292 |pmid = 14645538}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[carboxymethyluridine]]<sup>34</sup> in tRNA <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + 5-(2-methoxy-2-oxoethyl)uridine<sup>34</sup> in tRNA

The enzyme catalyses the [[posttranslational modification]] of [[uridine]] residues at the wobble position 34 of the [[anticodon]] loop of tRNA.

== References ==
{{reflist}}

== External links ==
* {{MeshName|TRNA+(carboxymethyluridine34-5-O)-methyltransferase}}

[[Category:EC 2.1.1]]