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{{DISPLAYTITLE:L-2-hydroxycarboxylate dehydrogenase (NAD<sup>+</sup>)}}
{{Infobox enzyme
| Name = L-2-hydroxycarboxylate dehydrogenase (NAD<sup>+</sup>)
| EC_number = 1.1.1.337
| CAS_number = 81210-65-3
| IUBMB_EC_number = 1/1/1/337
| GO_code = 
| image = 
| width = 
| caption =
}}
'''L-2-hydroxycarboxylate dehydrogenase (NAD<sup>+</sup>)''' ({{EC number|1.1.1.337}}, ''(R)-sulfolactate:NAD<sup>+</sup> oxidoreductase'', ''L-sulfolactate dehydrogenase'', ''(R)-sulfolactate dehydrogenase'', ''L-2-hydroxyacid dehydrogenase (NAD<sup>+</sup>)'', ''ComC'') is an [[enzyme]] with system name ''(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase''.<ref>{{cite journal | title = Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea |author = Graupner, M., Xu, H. and White, R. H. |journal = J. Bacteriol. |year = 2000 |volume = 182 |pages = 3688–3692 |pmid = 10850983 |doi=10.1128/JB.182.13.3688-3692.2000 |pmc=94539}}</ref><ref>{{cite journal | title = The first examples of (<em>S</em>)-2-hydroxyacid dehydrogenases catalyzing the transfer of the <em>pro</em>-4<em>S</em> hydrogen of NADH are found in the archaea |author = Graupner, M. and White, R. H. |journal = Biochim. Biophys. Acta |year = 2001 |volume = 1548 |pages = 169–173 |pmid = 11451450 |doi=10.1016/S0167-4838(01)00220-5}}</ref><ref>{{cite journal | title = Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics |author = Graham, D. E. and White, R. H. |journal = Nat. Prod. Rep. |year = 2002 |volume = 19 |pages = 133–147 |pmid = 12013276 |doi=10.1039/b103714p}}</ref><ref>{{cite journal | title = Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in <em>Paracoccus pantotrophus</em> NKNCYSA |author = Rein, U., Gueta, R., Denger, K., Ruff, J., Hollemeyer, K. and Cook, A. M. |journal = Microbiology |year = 2005 |volume = 151 |pages = 737–747 |pmid = 15758220 |doi=10.1099/mic.0.27548-0 |issue=Pt 3}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (2S)-2-hydroxycarboxylate + NAD<sup>+</sup> <math>\rightleftharpoons</math> 2-oxocarboxylate + NADH + H<sup>+</sup>

The enzyme from the [[archae]]on ''[[Methanocaldococcus jannaschii]]'' uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-[[malate]], (S)-[[Lactic acid|lactate]], and (S)-2-hydroxyglutarate.

== References ==
{{reflist}}

== External links ==
* {{MeshName|L-2-hydroxycarboxylate+dehydrogenase+(NAD+)}}

[[Category:EC 1.1.1]]