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{{Infobox enzyme
| Name = TRNA (adenine<sup>57</sup>-N<sup>1</sup>/adenine<sup>58</sup>-N<sup>1</sup>)-methyltransferase
| EC_number = 2.1.1.219
| CAS_number = 
| IUBMB_EC_number = 2/1/1/219
| GO_code = 
| image = 
| width = 
| caption =
}}
'''TRNA (adenine<sup>57</sup>-N<sup>1</sup>/adenine<sup>58</sup>-N<sup>1</sup>)-methyltransferase''' ({{EC number|2.1.1.219}}, ''TrmI'', ''PabTrmI'', ''AqTrmI'', ''MtTrmI'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:tRNA (adenine<sup>57</sup>/adenine<sup>58</sup>-N<sup>1</sup>)-methyltransferase''.<ref>{{cite journal | title = A primordial RNA modification enzyme: the case of tRNA (m<sup>1</sup>A) methyltransferase |author = Roovers, M., Wouters, J., Bujnicki, J.M., Tricot, C., Stalon, V., Grosjean, H. and Droogmans, L. |journal = Nucleic Acids Res. |year = 2004 |volume = 32 |pages = 465–476 |pmid = 14739239}}</ref><ref>{{cite journal | title = Insights into the hyperthermostability and unusual region-specificity of archaeal ''Pyrococcus abyssi'' tRNA m<sup>1</sup>A<sup>57/58</sup> methyltransferase |author = Guelorget, A., Roovers, M., Guerineau, V., Barbey, C., Li, X. and Golinelli-Pimpaneau, B. |journal = Nucleic Acids Res. |year = 2010 |volume = 38 |pages = 6206–6218 |pmid = 20483913}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 2 [[S-adenosyl-L-methionine]] + [[adenine]]<sup>57</sup>/adenine<sup>58</sup> in tRNA <math>\rightleftharpoons</math> 2 [[S-adenosyl-L-homocysteine]] + N<sup>1</sup>-methyladenine<sup>57</sup>/N<sup>1</sup>-methyladenine<sup>58</sup> in tRNA

The enzyme catalyses the formation of N<sup>1</sup>-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs .

== References ==
{{reflist}}

== External links ==
* {{MeshName|TRNA+(adenine57-N1/adenine58-N1)-methyltransferase}}

{{DEFAULTSORT:TRNA (adenine57-N1 adenine58-N1)-methyltransferase}}
[[Category:EC 2.1.1]]