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{{Infobox enzyme
| Name = Methionine-S-oxide reductase
| EC_number = 1.8.4.5
| CAS_number = 70248-65-6
| IUBMB_EC_number = 1/8/4/5
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Methionine-S-oxide reductase''' ({{EC number|1.8.4.5}}, ''methyl sulfoxide reductase I and II'', ''acetylmethionine sulfoxide reductase'', ''methionine sulfoxide reductase'', ''L-methionine:oxidized-thioredoxin S-oxidoreductase'') is an [[enzyme]] with system name ''L-methionine:thioredoxin-disulfide S-oxidoreductase''.<ref>{{cite journal | title = A specific enzymatic reduction of <small>L</small>-(-)methionine sulfoxide and a related nonspecific reduction of diulfides |author = Black, S., Harte, E.M., Hudson, B. and Wartofsky, L. |journal = J. Biol. Chem. |year = 1960 |volume = 235 |pages = 2910–2916 |pmid = }}</ref><ref>{{cite journal | title = Reduction of methionine sulfoxide to methionine by <em>Escherichia coli</em> |author = Ejiri, S.-I., Weissbach, H. and Brot, N. |journal = J. Bacteriol. |year = 1979 |volume = 139 |pages = 161–164 |pmid = 37234 |pmc=216841 |issue=1}}</ref><ref>{{cite journal | title = The purification of methionine sulfoxide reductase from <em>Escherichia coli</em> |author = Ejiri, S.-I., Weissbach, H. and Brot, N. |journal = Anal. Biochem. |year = 1980 |volume = 102 |pages = 393–398 |pmid = 6999943 |doi=10.1016/0003-2697(80)90173-6}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: L-[[methionine]] + [[thioredoxin disulfide]] + H<sub>2</sub>O <math>\rightleftharpoons</math> L-[[methionine]] S-oxide + [[thioredoxin]]

In the reverse reaction, [[dithiothreitol]] can replace reduced thioredoxin.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Methionine-S-oxide+reductase}}

[[Category:EC 1.8.4]]