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{{Infobox enzyme
| Name = Demethylrebeccamycin-D-glucose O-methyltransferase
| EC_number = 2.1.1.164
| CAS_number = 
| IUBMB_EC_number = 2/1/1/164
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Demethylrebeccamycin-D-glucose O-methyltransferase''' ({{EC number|2.1.1.164}}, ''RebM'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase''.<ref>{{cite journal | title = RebG- and RebM-catalyzed indolocarbazole diversification |author = Zhang, C., Albermann, C., Fu, X., Peters, N.R., Chisholm, J.D., Zhang, G., Gilbert, E.J., Wang, P.G., Van Vranken, D.L. and Thorson, J.S. |journal = Chembiochem |date = 2006 |volume = 7 |pages = 795–804 |pmid = 16575939 | doi = 10.1002/cbic.200500504 | issue = 5}}</ref><ref>{{cite journal | title = Structure and mechanism of the rebeccamycin sugar 4&prime;-<em>O</em>-methyltransferase RebM |author = Singh, S., McCoy, J.G., Zhang, C., Bingman, C.A., Phillips, G.N., Jr. and Thorson, J.S. |journal = J. Biol. Chem. |date = 2008 |volume = 283 |pages = 22628–22636 |pmid = 18502766 | doi = 10.1074/jbc.M800503200 | issue = 33 | pmc = 2504894}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 4'-demethylrebeccamycin + [[S-adenosyl-L-methionine]] <math>\rightleftharpoons</math> [[rebeccamycin]] + [[S-adenosyl-L-homocysteine]]

Demethylrebeccamycin-D-glucose O-methyltransferase catalyses the last step in the biosynthesis of [[rebeccamycin]], an [[indolocarbazole]] [[alkaloid]] produced by the ''[[Actinobacterium Lechevalieria]]'' aerocolonigenes.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Demethylrebeccamycin-D-glucose+O-methyltransferase}}

[[Category:EC 2.1.1]]